The Influence Of Anxiety And Depression On The Relapse Of Alcohol Dependence

Objective:To explore the influence of anxiety and depression on the relapse of alcohol dependence.Methods:A prospective research method was used to select inpatients who met the diagnosis of alcohol dependence in A Mental Health Center from January 2019 to September 2020 as the research subjects.The baseline survey included social demography and clinical characteristics of substance use.GAD-7 anxiety scale was used to measure the anxiety level of patients,and PHQ-9 Depression scale was used to measure the level of depression.The patients were followed up for 6 months after discharge,and the recurrence was taken as the outcome index.Through the statistical analysis of software SPSS19.0,P<0.05.There was statistical significance.Results:1.Research 0ne:during the follow-up of 1,3 and 6 months after discharge,the continuous withdrawal rate of moderate and severe anxiety alcohol addicts was lower than that of non-anxiety group and mild anxiety group.Six months after discharge,the continuous abstinence rates of alcohol addicts in non-anxiety group,mild anxiety group and moderate and severe anxiety group were 38.64%,41.25%and13.16%,respectively.The continuous withdrawal rate of the non-anxiety group and the mild anxiety group changed with time,while the continuous withdrawal rate of the moderate and severe anxiety group decreased more rapidly after discharge(χ~2=9.860,P=0.007).2.Research two:during the follow-up of 1,3 and 6 months after discharge,the continuous withdrawal rate of moderate and severe depressive alcohol addicts was lower than that of non-depression group and mild depression group.Six months after discharge,the continuous withdrawal rates of non-depression group,mild depression group and moderate to severe depression group were 45.31%,44.29%and 16.67%,respectively.The continuous withdrawal rate of the non-depression group and the mild depression group changed with time,while the continuous withdrawal rate of the moderate and severe depression group decreased more rapidly after discharge(χ~2=16.29,P<0.001).3.Research three:during the follow-up at 1,3 and 6 months after discharge,the continuous withdrawal rate of the non-anxiety-depression tendency group was higher than that of the anxiety or depression tendency group and the anxiety-depression tendency group.Six months after discharge,the continuous withdrawal rates of non-anxiety-depression tendency group,only anxiety or depression tendency group and anxiety-depression tendency group were 46.03%,22.00%and 10.00%respectively.Only the continuous withdrawal rate in the anxiety or depression tendency group was similar to that in the anxiety-depression tendency group,while the continuous withdrawal rate in the non-anxiety-depression tendency group decreased more slowly after discharge(χ~2=19.50,P<0.001).4.Univariate analysis of social demography and clinical characteristics of substance use showed that daily drinking(χ~2=4.80,P=0.05),anxiety and depression(χ~2=19.50,P=0.003)and educational background(χ~2=8.561,P=0.003)were the prognostic factors of alcohol dependence(P=0.05).Further Cox proportional hazard regression analysis showed that daily alcohol consumptionχ~2=4.80,P=0.05),anxiety and depression(χ~2=19.50,P=0.003)and education(χ~2=8.561,P=0.003)were the prognostic factors of alcohol dependence.The independent variables with statistical significance were anxiety or depression(HR=1.772,P=0.005),anxiety combined with depression(HR=2.188,P=0.001).There was no significant difference in drinking frequency and education level(P>0.05).Conclusion:The recurrence rate of moderate to severe anxiety was higher than that of alcohol dependence without anxiety and mild anxiety,and the recurrence rate of moderate to severe depression was higher than that of alcohol dependence without depression and mild depression.the recurrence rate of alcohol dependence in anxiety-depression tendency group was higher than that in non-anxiety-depression tendency group and only anxiety or depression tendency group.Anxiety and depression are prognostic factors of alcohol dependence recurrence.