| Objective: The study reviewed the relevant literature of clinical trials on antihypertensive treatment in elderly hypertensive patients and used a systematic evaluation method to analyze the correlation between antihypertensive treatment and cardiovascular and cerebrovascular events or all-cause mortality in elderly hypertensive patients.Methods: The literatures from January 1900 to January 2020 on randomized controlled trials of antihypertensive treatment of elderly hypertension were collected.Chinese databases including CNKI China Knowledge Network,Chinese Biomedical Literature Database,Vip Database,Wanfang Database,Chinese Science and Technology Periodical Full-text Database(VIP)and English Databases including Pub Med,Sino Med,Medline,Nature,Cochrane Library,EMbase,CBMdiasc and other databases were searched.The search terms in English included “very old people,elderly(older)people,in the older,in older adult,elderly hypertension patients,hypertension,high blood pressure,randomized control trial,goal blood pressure”,and the search terms in Chinese included “elderly people,senior citizens,elevated blood pressure,hypertension,hypertension treatment,randomized controlled trials,blood pressure levels”.Moreover,related synonyms were considered as well.Selection of the retrieved documents in terms of the inclusion and exclusion criteria.The inclusion criteria were as follows,(1)Clinical randomized controlled trials published in Chinese or English from January 1900 to January 2020 with placebo as the control group,and the original data of the trial is complete;(2)The study objectives were primary hypertension patients with aged 80 years or older,regardless of country and ethnicity,follow-up time over 2 years;sample size greater than 200 people;(3)Oral antihypertensive drug;(4)The indicators of assessment endpoint were the incidence of non-fatal stroke events,the incidence of non-fatal cardiovascular events and all-cause mortality.Exclusion criteria were as follows,(1)Duplicate publication and review articles;(2)non-randomized controlled clinical trials;(3)Animal experiments.Then the quality of the literature were assessed and the data was extracted.The datawas analyzed using Rev Man5.3 software.According to the statistical results,analyze the correlation between antihypertensive therapy and non-fatal stroke events,non-fatal cardiovascular events or all-cause death events in elderly hypertensive patients.Results: The retrieval is accomplished by the search term.A total of 4randomized controlled trials were included.The quality evaluation of the included studies was low in bias and then the data were extracted.There were 5171 objectives.2617 patients in the experimental group,including 99 patients with non-fatal stroke events,237 patients with non-fatal cardiovascular events,and 336 patients with all-cause death;2554 patients with control group,including non-fatal There were 135 patients with stroke events,314 patients with non-causative cardiovascular events,and 355 patients with all-cause deaths.Use the Rev Man5.3 software for statistical analysis and draw conclusions.Conclusion: Antihypertensive therapy can reduce the risk of cardiovascular and cerebrovascular events in elderly patients with hypertension,but there is no significant difference in reducing the risk of all-cause death compared with the control group. |
