The Impact Of Non-alcoholic Fatty Liver Disease On Bone Mineral Density Of Lumbar Spine In Type 2 Diabetes Mellitus

Objective:To evaluate the association between Nonalcoholic fatty liver disease(NAFLD)and lumbar spine bone mineral density(BMD)in type 2 diabetes mellitus(T2DM).Methods:Dual-energy X-ray absorptiometry(DXA)was used to measure the Lumbar BMD of 1088subjects.Liver fat content was measured by ultrasound.According to the clinical diagnosis,they were divided into T2DM and non diabetes groups.The two groups were further divided into NAFLD and non-NAFLD groups.The student’s t-test assessed the difference in lumbar BMD between NAFLD and non-NAFLD groups.Multivariate linear regression analysis was performed to evaluate the relationship between lumbar BMD and NAFLD.Results:1 The lumbar BMD in the T2DM group and the non diabetesgroup was higher in the NAFLD group than the non-NAFLD group(P<0.001).2 Multivariate regression analysis in the T2DM group found that after adjusting for sex,age,BMI,uric acid,blood lipids,calcium and glycosylated hemoglobin,alanine aminotransferase,the association between lumbar spine BMD and NAFLD remained(β coefficient:-0.488,95%CI:-0.921--0.055,P=0.027).In the non diabetes group,after adjusting for sex,age,BMI,alanine aminotransferase,triglyceridesand uric acid,the association between NAFLD and lumbar spine BMD disappeared.Conclusions:The lumbar BMD of NAFLD patients is higher than that of non-NAFLD patients.After adjusting for confounding factors,lumbar BMD was relevant with NAFLD in T2DM patients but not in non diabetes patients.