Correlation Study Of Osteoporosis And Influence Factor Measurement By Quantitative CT

Objective: Osteoporosis(Osteoporosis, OP) has been one of the high incidences in today’s society, especially in middle and aged people, and postmenopausal women. It is a systemic bone disease which the main complication is various fragility fractures, due to the bone loss, damage to bone quality and reduced bone strength.Osteoporosis, as one of the most common complication of diabetes, gets the death and disability rate increased significantly, and seriously affects the patients’ life. Therefore for further study the correlation between osteoporosis and age, body mass index( BMI), abdominal area, abdominal weight, and the correlation between the related hormone levels of diabetic patients and Osteoporosis, we do a statistical analysis by testing and inquiring different aspects from two different groups of people: 1) the gender, age, BMI, diabetes history of the ordinary patients who come to Hebei Medical University, the 3rd Hospital for making a CT; 2) the blood biochemical index for the diabetes patients in our endocrinology department, e.g. PTH, CT, blood pressure, blood insulin levels, blood calcium, phosphorus and bone mineral density, etc.Methods:1 Choose randomly 217 hospitalized diabetic patients and 229 non-diabetic patients from our endocrinology department.2 Use Sensasion Siemens 16 row helical CT scanner to scan, and process by QCT post-processing software automatically, for the measurement of the BMD of L1~L3 interested area, abdominal area and abdominal weight.3 Compare all groups of measured data by SPSS13.0: a) Compare the general condition index between the two groups, e.g. age, BMI, abdominal area, abdominal weight, and the L1~L3 bone mineral density, b) Compare two groups separately for the correlation between the L1~L3 BMD and gender, age. abdominal area, abdominal weight, c) the two groups’ comparison between normal bone mass, bone mass reduction and osteoporosis BMD, d) the correlation between BMD and blood pressure, blood sugar, insulin, blood calcium and blood phosphorus in diabetic group.Results:1 L1 ~ L3 bone mineral density is highly statistically significant(P < 0.01) in comparison the diabetic and non-diabetic group;2 BMD composition is statistically significant in comparison the diabetic and non-diabetic group(P < 0.05);3 Compare separately the two groups for the correlation between L1~L3 BMD and gender, age, BMI, abdominal area, and abdominal weight, a) L1~L3 BMD of diabetic group is inversely correlated with age, abdominal weight, while positively associated with abdominal area; b) L1,and L3 BMD of non-diabetic group is inversely correlated with age, and positively associated with gender, L3 BMD is inversely correlated with age;4 BMD is inversely correlated with blood pressure, blood glucose, blood insulin, blood calcium and phosphorus.Conclusion:1 L1~L3 BMD of the diabetic group is lower than non-diabetic group, and BMD is statistically significant(P < 0.05);2 the old age is a high risk factor of osteoporosis.3 The BMD of women is lower than men in L1~L3 BMD of the diabetic group.4 In patients with diabetes, BMD increased with BS.5 In patients with diabetes, high blood pressure is a high risk factor of osteoporosis.