Study On The Association Between Metabolic Syndrome And Thyroid Volume In Adolescents

Background:A variety of physiological and pathological factors can lead to thyroid enlargement in adolescents.Currently,goiter caused by iodine deficiency in adolescents is rare in China.In recent years,studies based on adults have found that increased thyroid volume is associated with metabolic disorders,while relevant data based on adolescents are scarce.At the same time,the prevalence of metabolic syndrome in Changzhou area remains unclear.Objective:To explore the association between thyroid volume and metabolic syndrome in adolescents,and to explore the components of abnormal metabolic syndrome and related biochemical indexes that affect thyroid volume.To investigate the prevalence of metabolic syndrome among adolescents in this region.Methods:A total of 1 097 middle school students aged between 12-15 years old(55.6%males)were enrolled.All the participants underwent physical examination,biochemical test,and thyroid gland ultrasonography.The thyroid volume of normal,overweight and obese group was compared.The association between the number of metabolic syndrome components and thyroidvolume was analyzed.The association between metabolic parameters and thyroid volume was also analyzed.Results:The difference in thyroid volume between the metabolic syndrome group and the non-metabolic syndrome group was statistically significant(t=3.62,P<0.01).There was no significant difference in thyroid volume among groups with each single metabolic syndrome component(F=0.16,P=0.96).Among groups with different number of metabolic syndrome components,the difference of thyroid volume was significantly different(F=10.64,P<0.01).Simple linear regression indicated that the parameters positively correlated with thyroid volume in adolescents included height,weight,waist circumference,hip circumference,BMI,systolic pressure,fasting insulin HOMA-IR triglyceride and uric acid,and the parameters negatively associated with thyroid volume in adolescents were HDL-C(P all<0.05).According to multiple regression model,parameters with significant association with thyroid volume were gender(β=0.607,95%CI:0.406,0.808;P<0.01),age(β=0.200,95%CI:0.107,0.294;P<0.06),systolic blood pressure(β=0.010,95%CI:0.002,0.018;P=0.014),waist circumference(β=0.029,95%CI:0.015,0.042;P<0.01)and the waist-to-height ratio(β=3.317,95%CI:1.661,4.973;P<0.01),The thyroid volume of adolescents with central obesity combined with other metabolic disorders was significantly larger than that of other metabolic phenotype groups(F=5.43,(P=0.01).The prevalence of metabolic syndrome among adolescents in Changzhou was 2.3%.Conclusion:Metabolic syndrome is closely related to adolescent thyroid enlargement.Central obesity is the most important risk factor for thyroid enlargement.The prevalence of metabolic syndrome among adolescents in Changzhou was 2.3%.