Study On The Relationship Between Obesity,Abnormal Glucose Metabolism And Thyroid Nodules,Thyroid Volume In Shanxi

With the prevalence of metabolic syndrome increased year by year,thyroid disease has become a very common endocrine disease at home and abroad.The metabolic syndro-me in obese,insulin resistance is characterized by many factors,then obesity is genetic and environmental interactions caused by excessive accumulation of fat or with abnormal distribution of chronic metabolic diseases increased weight.In the last 10 years,a thyroid associated with obesity has achieved remarkable results,which is growing evidence link-ing obesity and increased risk of cancer among the epidemiological data support,and the incidence of obesity is independent of various solid tumors related to the rate of increase,including thyroid cancer,but the exact mechanism of obesity and thyroid tumor has not yet been elucidated.Inflammation,oxidative stress,insulin-axis IGF and adipokines(such as leptin,adiponectin in obesity and may)and the occurrence of benign and malignant thyroid nodules Play a pivotal role in the development process.Obesity especially central obesity greatly improves cardiovascular and cerebrovascular diseases,metabolic diseases and tumors(solid tumors were).The risk of body mass index(BMI)as the evaluation index of common obesity has been confirmed,closely related with many diseases,in recent years,many researches showed that the relationship between central obesity and the disease is more closely.Obesity index evaluation center waist circumference,waist to height ratio,many articles reported on the judgment of waist height of central obesity than waist to high efficiency evaluation.The reason may be that there is a certain effect of height on waist circumference in the evaluation of central obesity.Objective:To investigate the differences of blood glucose(fasting and ogtt-2hours),glycosylated hemoglobin,BMI,waist circumference,waist height ratio and other indicators of the urban and rural population in Shanxi Province.Analysis of blood glucose,BMI,waist circumference,waist to height ratio of thyroid nodules(nodule size,solitary nodules),thyroid volume.To provide different preventive measures for metabolic syndrome in different populations,then explore the risk factors of thyroid disease and to provide effective preventive measures.Methods:selected Shanxi Province as the research object,the total sample size n=2658.The inclusion criteria: survey area(refers to the city or agricultural county)of the household population,and the residence time in more than five years;At the age of 18;except for gestational age and lactation women.We use multistage stratified cluster random sampling method.The scene investigation crowd city survey of 1396 people,1262 people of the rural were investigated.Age composition is divided into 6 age groups: age 18-29 years,30-39 years,40-49 years,50-59 years,60-69 years old,more than 70 years old.Site registration for the survey,and fill in the questionnaire,then physical examination of the survey: height,weight,waist circumference,thyroid palpation,parallel thyroid B Ultrasound.We collect blood,then on-site centrifugation,packing,numbering,samples were sent to the central laboratory testing.The test results record into the database,and the field survey results guide for further examination and treatment.Last,we collated and analyzed the experimental data.Results:1.Rural IFG rate than city IFG was significantly higher,the difference was statistically significant(x2=8.188 p=0.004);the abnormal detection rate of rural OGTT-2 hours pathoglycemia than city abnormality rate was significantly increased,the difference was statistically significant(x2=24.342 p<0.001);However,there was nosignificant difference in HbA1 c between rural and urban areas(p=0.899);The subjects were divided into three groups: normal,overweight and obesity by BMI and the difference was not statistically significant(p=0.126);The abnormal detection rate of a city rural waist circumference increased,the difference was statistically significant(x2=46.256 p<0.001);The abnormal rate of rural waist to height ratio increased than the city’s,the difference was statistically significant(t =22.460 p<0.001).2.Logistic regression analysis showed that the thyroid volume which has the higher the waist to height ratio is larger than the opposite side.3.Logistic regression analysis showed that the possibility of multiple nodules which have higher fasting blood glucose and OGTT-2 hours blood glucose are the higher than the opposite side.4.Logistic regression analysis showed that the possibility of the nodule≥1cm which have the higher the blood glucose of OGTT-2 hours is higher than the opposite side.Conclusions:1.Rural IFG rate than city IFG was significantly higher;the abnormal detection rate of rural OGTT-after 2 hours pathoglycemia than city abnormality rate was significantly increased;and the central obesity detection rate of rural is significantly increased then the city’s.2.The thyroid volume which has the higher the waist to height ratio is larger than the opposite side.3.The possibility of multiple nodules which have higher fasting blood glucose and OGTT-2 hours blood glucose are the higher than the opposite side.4.The possibility of the nodule≥1cm which have the higher the blood glucose of OGTT-2 hours is higher than the opposite side.