| Objective:Through the treatment of Ulcerative colitis(UC)of Anchang decoction by oral combined retention enema,observe the clinical comprehensive curative effect and adverse reaction,aims at making a comprehensive evaluation of an Chang Decoction clinical efficacy and safety,to provide new ideas for clinical application and promotion and UC treatment of Anchang decoction.Methods:The hospital in accordance with the inclusion criteria of 45patients with non severe ulcerative colitis patients with an visiting sequence were randomly divided into treatment group(treatment group 1:Anchang Decoction oral+mesalazine oral;treatment group 2:Anchang Decoction Oral+Enema)and control group(mesalazine oral),a total of three group,15cases in each group.4 weeks of treatment(2 weeks as a course of treatment),the 4 groups were examined in laboratory observation before and after treatment(WBC,CRP)level,comprehensive clinical efficacy,endoscopic mucosal improvement,major symptom(mucous bloody stool,diarrhea,abdominal pain)relief,security and the use of statistical analysis.Results:(1)The three groups of patients were evenly distributed in age,sex,duration,condition,range of disease and basic treatment.There was no statistically significant difference in the data between the three groups(P>0.05),which was comparable.(2)After treatment,three groups of white blood cells(WBC)and C-reactive protein(CRP)levels were significantly reduced than before,by random design analysis of variance test,there was no significant difference in the level of white blood cell(WBC)between the three groups before and after treatment(P>0.05).There was a significant difference in the level of C-reactive protein(CRP)before and after treatment(P<0.05),and there was no significant difference between the three groups(P>0.05).(3)In the clinical curative effect after treatment.In the treatment group 1:5 cases were relieved,9 cases were effective and 1 cases were ineffective,the total effective rate was 93.33%.In the treatment group 2:7 cases were relieved,7cases were effective and 1 cases were ineffective,the total effective rate was93.33%.In the control group:3 cases were alleviated,6 cases were effective,6cases were invalid,the total effective rate was 60%,the difference between the three groups was statistically significant(X~2=6.424,P=0.04).(4)In the improvement of the mucous membrane after treatment.In the treatment group1:5 cases were relieved,7 cases were effective and 3 cases were ineffective,the total effective rate was 80%.In the treatment group 2:remission:8 cases,effective 6 cases,1 cases ineffective,the total effective rate is 93.33%;In the control group:2 cases were relieved,7 cases were effective,6 cases were invalid,the total effective rate was 60%.The difference of mucosal improvement between the three groups was statistically significant(X~2=7.258,P=0.027).(5)After treatment,the scores of the main symptoms of the three groups were significantly reduced.Comparison between any two found that:In the bloody mucus:the treatment group 2 compared with the control group,the difference was statistically significant(P<0.05),the treatment group 1 and the treatment group 2,the control group,the difference was not statistically significant(P>0.05);In the area of abdominal pain and diarrhea:there was no significant difference between the treatment group 1 and the treatment group2(P>0.05);the difference between the treatment group 1 and the treatment group 2 was statistically significant compared with the control group(P<0.05).Conclusion:(1)There is no significant reference value of clinical common white blood cells(WBC)and C-reactive protein biochemical indicators in UC treatment and disease assessment,only as an excessive reference..(2)The TCM Anchang decoction can synergistically enhance the therapeutic effect of mesalazine,at the same time,it can effectively relieve the side effects caused by mesalazine and improve the tolerance to mesalazine,and the long-term effect is worth exploring.(3)The TCM Anchang decoction enema efficacy in repairing an intestinal lesion of UC in colonic mucosa of patients with low aspect is more advantages than the mesalazine oral,and the curative effect is more obvious.(4)The TCM Anchang decoction in improving UC patients with abdominal pain and mucus pus and blood than the salad oral more advantages,and the effect of enema is more obvious.(5)The curative effect of oral combined retention enema for UC has obvious advantages,the clinical effect is better than that of simple oral or incling enema.and it can give full play to the clinical effect of Chinese medicine an intestinal soup.It is worth further digging and popularizing. |
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