Correlation Analysis Of Serum NT-proBNP And Ca²⁺ Levels With Hypertensive Intracerebral Hemorrhage And Severity Of Illness

ObjectiveThe levels of N-terminal pro brain natriuretic peptide（NT-proBNP）and calcium ions(Ca²⁺)were measured in healthy subjects as well as in hypertensive intracerebral hemorrhage subjects to investigate the correlation between the levels of these two indexes and the cerebral hemorrhage volume and the severity of the disease.Considering that these two indicators are easy to detect and convenient in clinic,whether the occurrence of hypertensive intracerebral hemorrhage can be predicted or the condition and the cerebral hemorrhage volume can be estimated by detecting the levels of these two indicators in serum,which will provide a new way for clinical diagnosis and prevention of hypertensive intracerebral hemorrhage and provide a theoretical basis for the development of drugs related to hypertensive intracerebral hemorrhage.MethodsIn this study,90 patients with hypertensive cerebral hemorrhage（cerebral hemorrhage group）and 90 healthy patients（control group）who were diagnosed with hypertensive cerebral hemorrhage during the period of October 2016 to October 2020 in the neurosurgery department of the Second Affiliated Hospital of Shenyang Medical College were selected for this study.The onset time of all patients with cerebral hemorrhage was less than8 hours.Record the relevant information of the patient,such as the patient’s hospital number,name,gender,age,etc.,and ask if there is a history of smoking,hypertension,diabetes,etc.Measure the values of relevant indicators by relevant instruments,including NT-proBNP and Ca²⁺ levels（no more than 24 hours from onset to blood test）.On the basis of CT images,the intracerebral hemorrhage volume in the experimental group was measured by the formula of takada（π/6 length× width×number of layers）,and the intracerebral hemorrhage group was divided into three groups according to how much the volume of the intracerebral hemorrhage occurred: 26 patients in the small volume intracerebral hemorrhage group（less than 10 ml）,35 patients in the medium volume intracerebral hemorrhage group（10-30 ml）,and 29 patients in the large volume intracerebral hemorrhage group（more than 30 ml）.After admission,the Glasgow Coma Score（GCS）was performed on patients with hypertensive cerebral hemorrhage,and the cerebral hemorrhage was divided into three groups according to the GCS score: light group（GCS: 13-15 points,n=47）,medium group（GCS: 9-12 points,n=23）,heavy group（GCS: <9 points,n=20）.The statistical software spss23.0 was used to analyze the data,and the levels of NT-proBNP and Ca²⁺in serum were analyzed to correlate with the cerebral hemorrhage volume and the severity of illness.The relationships between serum NT-proBNP and Ca²⁺levels with GCS score and intracerebral hemorrhage volume were analyzed by linear analysis.The t-test was applied for data that conformed to normal distribution,the nonparametric test was applied for data that did not conform to normal distribution,the chi square test was applied for dichotomous variables,and the analysis of variance was applied for data with multiple groups.Results1.The serum NT-proBNP level in the hypertensive intracerebral hemorrhage group was higher than that in the healthy control group（P<0.05）.2.The serum Ca²⁺level in the hypertensive intracerebral hemorrhage group was lower than that in the healthy control group（P <0.05）.3.In the hypertensive intracerebral hemorrhage group,the serum NT-proBNP level in the large cerebral hemorrhage group was higher than that in the medium hemorrhage group and the small cerebral hemorrhage group,and the serum NT-proBNP level in the medium cerebral hemorrhage group was higher than that in the small cerebral hemorrhage group（P<0.05）.4.In the hypertensive intracerebral hemorrhage group,the serum Ca²⁺level was higher in the small volume intracerebral hemorrhage group than in the medium volume and large volume intracerebral hemorrhage groups,and the serum Ca²⁺level was higher in the medium volume intracerebral hemorrhage group than in the large volume intracerebral hemorrhage group（P <0.05）.5.In the hypertensive intracerebral hemorrhage group,the serum NT-proBNP level was higher in the severe cerebral hemorrhage group than in the medium-sized and mild cerebral hemorrhage groups,and it was higher in the medium-sized cerebral hemorrhage group than in the mild cerebral hemorrhage group（P <0.05）.6.In the hypertensive intracerebral hemorrhage group,the serum Ca²⁺level of the severe intracerebral hemorrhage group was lower than that of the medium intracerebral hemorrhage group and the mild intracerebral hemorrhage group,and the serum Ca²⁺ level of the medium intracerebral hemorrhage group was lower than that of the mild intracerebral hemorrhage group（P<0.05）.7.NT-proBNP levels in serum of hypertensive intracerebral hemorrhage patients are positively correlated with intracerebral hemorrhage volume and negatively correlated with GCS score.8.Serum Ca²⁺ levels in hypertensive intracerebral hemorrhage patients are negatively correlated with intracerebral hemorrhage volume and positively correlated with GCS score.ConclusionSerum NT-proBNP and Ca²⁺levels have a certain correlation with hypertensive intracerebral hemorrhage,which may have predictive value for the occurrence of intracerebral hemorrhage.Pay close attention to the occurrence of cerebral hemorrhage when the serum NT-proBNP level in hypertensive patients increases and the Ca²⁺ level decreases.Serum NT-proBNP level in patients with hypertensive intracerebral hemorrhage is positively correlated with cerebral hemorrhage volume and negatively correlated with GCS score.The higher the serum NT-proBNP level,the greater the intracerebral hemorrhage volume and the more severe the condition.Serum Ca²⁺level in patients with hypertensive cerebral hemorrhage is negatively correlated with cerebral hemorrhage volume,and positively correlated with GCS score.The lower the serum Ca²⁺level,the greater the intracerebral hemorrhage volume and the more severe the condition.The volume of cerebral hemorrhage and the severity of the patient’s condition can be roughly estimated by detecting the levels of serum NT-proBNP and Ca²⁺,providing certain value for the prevention,diagnosis and treatment of hypertensive cerebral hemorrhage.