| Objective: to evaluate objectively the clinical effect of Huoxue Xiaozhitong prescription on swelling and pain of children with supracondylar fracture of humerus by observing and comparing the curative effect of three groups of drugs on the treatment of swelling and pain,so as to provide reliable basis for popularizing the clinical application of this prescription.Methods: from October 2017 to October 2018,60 children with supracondylar fracture of humerus,who were treated in the Department of Pediatric Orthopaedics,affiliated Hospital of Shandong University of traditional Chinese Medicine,were selected.The age range was from 3 to 6 years old.Three study groups were formed randomly from the patients,each group has 20 patients,and each group received different treatment before operation.The three groups were Huoxue Xiaozhouzhitong recipe group(hereinafter referred to as traditional Chinese medicine group),herbal rhinoceros extract group(hereinafter referred to as western medicine group),starch tablet group(hereinafter referred to as the control group).All of the patients in the three groups were treated with forearm and chest suspension after admission,and all of them were treated three days before admission.The treatment will be stopped on the day of the operation.The first day of treatment,the first day of treatment,the second day of treatment,the pain points of the elbow,the degree of swelling and the integral,the complications,the function of the liver and the kidney,and the like were observed.The data of 60 patients were treated with the statistical software(SPSS21.0),and the clinical effects of the three groups were evaluated by comparing the change of the observation indexes of the three groups.Results of the study:Comparison: Among the three groups there was no obvious difference in age,sex,swelling and pain of affected limbs,sleep time,finger joint activity,capillary reaction test,white blood cell and C-reactive protein.Comparison of elbow swelling score: there was no significant difference between the three groups before treatment(P > 0.05),and there was no significant difference between the three groups on the first day of treatment and before treatment(P > 0.05).On the second day of treatment,there was obvious difference between the Chinese medicine group and the pre-treatment group(P < 0.05),but there was no difference among the other two groups(P > 0.05).On the third day of treatment,there was a significant difference between the Chinese medicine group and the pre-treatment group(P < 0.01).There was a difference between the western medicine group and the pre-treatment group(P < 0.05),but there was no difference between the control group and the pre-treatment group(P > 0.05).There was significant difference between the other two groups(P < 0.05).Comparison of swelling degree of elbow joint: there was no significant difference between the three groups before treatment(P > 0.05),but there was no difference between the three groups on the first day of treatment and before treatment(P > 0.05).On the second day of treatment,there was obvious difference between the Chinese medicine group and the pre-treatment group(P < 0.05),but there was no difference among the other two groups(P > 0.05).On the third day of treatment,there was a significant difference between the Chinese medicine group and the pre-treatment group(P < 0.01),but there was no difference between the western medicine group and the western medicine group(P < 0.05),but there was no difference between the control group and the control group before treatment(P > 0.05).Comparison between the traditional Chinese medicine group and the other two groups There was significant difference(P < 0.05).Comparison of the effects of elbow joint swelling elimination: on the first day of treatment,there was no difference in the effect of detumescence among the three groups(P > 0.05);On the second day of treatment,there was a difference between the Chinese medicine group and the other two groups(P < 0.05),but there was no difference between the other two groups(P > 0.05).On the third day of treatment,there was obvious difference between the Chinese medicine group and the other two groups(P < 0.05),but there was no obvious difference among the other two groups(P > 0.05).Comparison of pain score of elbow joint: there was no significant difference in pain score between the three groups on admission(P > 0.05),but there was significant difference between the traditional Chinese medicine group and the other two groups on the first day of treatment(P < 0.05).On the second day of treatment,there was significant difference between the traditional Chinese medicine group and the other two groups(P < 0.01),but on the third day,there was no significant difference among the three groups(P > 0.05).Comparison of sleep time: there was no significant difference in normal sleep time among the three groups(P > 0.05),but on the first day of treatment,there was a significant difference in the length of sleep between the traditional Chinese medicine group and the other two groups(P < 0.05).On the second day of treatment,there was significant difference between the traditional Chinese medicine group and the other two groups(P < 0.01),but on the third day,there was no significant difference in the sleep time among the three groups(P > 0.05).Comparison of finger joint mobility: there was no obvious difference among the three groups(P > 0.05)before treatment,and there was still no obvious difference among the three groups on the first day of treatment(P > 0.05).On the second day of treatment,there was difference between the traditional Chinese medicine group and the pre-treatment group(P < 0.05),but there was no difference between the other two groups as compared with the pre-treatment group.On the third day of treatment,there was significant difference between the traditional Chinese medicine group and the pre-treatment group(P < 0.01),but there was no difference between the western medicine group and the pre-treatment group(P < 0.05),while there was no difference between the control group and the pre-treatment group(P > 0.05).There was significant difference between the traditional Chinese medicine group and the other two groups.The difference was significant(P < 0.05).Capillary reaction test: there was no obvious difference among the three groups(P > 0.05)before treatment,and there was no obvious difference between the three groups on the first day of treatment(P > 0.05).On the second day of treatment,there was difference between the two groups before treatment(P < 0.05),but there was no difference between the other two groups before treatment(P > 0.05).On the third day of treatment,there was significant difference between the traditional Chinese medicine group and the pre-treatment group(P < 0.01),and there was significant difference between the western medicine group and the pre-treatment group(P < 0.05),while there was no difference between the control group and the pre-treatment group(P > 0.05).There was significant difference between the drug group and the other two groups(P < 0.05).Comparison of blood routine and C-reactive protein: there was no significant difference in the incidence of leukocyte or C-reactive protein abnormality in the three groups before treatment.The incidence of abnormal leukocyte or C-reactive protein in the three groups was significantly lower than that in the other two groups,but there was no significant difference between the other two groups.Comparison of incidence of complications: no adverse reactions and complications were observed in all three groups of children treated during the whole course of this study.Comparison of the indexes of liver and kidney function and coagulation: the four indexes of liver and kidney function and coagulation were within the normal range before and after treatment,and there was no significant difference between the three groups.Conclusion: Huoxue Xiaozhongzhitong prescription can reduce the time of eliminating pain in supracondylar fracture of humerus,shorten the period of eliminating swelling,improve the microcirculation of local blood flow,alleviate the local inflammatory reaction,and it is safe to use medicine.The prescription has clinical effect in eliminating swelling and pain of supracondylar fracture of humerus and provides basis for its clinical application in the future. |
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