Study Of The Psoriatic Arthritis-related Metabolic Syndrome

Objectives: 1.To explore the incidence rate and risk factors of the metabolic syndrome associated with psoriatic arthritis.2.To explore the effects of metabolic indicators on psoriatic arthritis patients.Methods: 1.Clinical data were collected from 136 patients with a clear diagnosis and complete data on psoriatic arthritis.Statistical processing was performed using the SPSS20.0 software.2.Serum from 36 patients with psoriatic arthritis were collected,and 40 healthy individuals were collected,and serum erythropoietin and chemookine ligands 20 concentration was measured by enzyme-linked immunosorbent assay（ELISA）for statistical analysis.Results:1.In psoriatic arthritis patients,there were 26 patients with a combined metabolic syndrome.The prevalence rate of 23%.2.Patients with psoriatic arthritis combined with the metabolic syndrome had a higher body mass index,fasting blood glucose,triglycerides,systolic,and diastolic blood pressure（p <0.001,p<0.001,p <0.001,p=0.009,p=0.037,respectively）.Psoriatic arthritis patients with metabolic syndrome were older and had higher hemoglobin and urea nitrogen concentrations（53 years vs 45 years p=0.006,128 g / l vs 116 g / l p=0.011,6.1mmol/L vs 5.0 mmol/L p=0.020）.Psoriatic arthritis patients without metabolic syndrome had higher concentrations of platelets and C-reactive protein（306.9 * 10 ^ 9 / L vs 251.2 * 10 ^ 9 / L p=0.024,58.9mg/L vs 34.6mg/L p=0.033）.3.Patients with psoriatic arthritis smoking are more prone to metabolic syndrome（46.7% vs 17.9% p=0.001）.4.Metabolic indicators in Ps A patients: Patients with high triglycerides and BMI had higher red blood cell and hemoglobin concentrations than Ps A patients（p <0.05）.Patients with high blood pressure had higher RBC concentrations compared to normotensive Ps A patients（p <0.05）.5.The concentration of erythropoietin is significantly higher in patients with psoriatic arthritis than in healthy people（16.5ml U/m L vs 9.5ml U/m L p=0.006）.6.The concentration of chemokine ligand 20 was significantly higher in psoriatic arthritis patients than in healthy patients（85.5pg/m L vs 40.2pg/m L p=0.001）.Conclusions:Patients with psoriatic arthritis are prone to a combined metabolic syndrome.Smoking may be a risk factor for developing the metabolic syndrome.The concentration of red blood cells in patients with Ps A with abnormal metabolism is elevated.