| Purpose:The clinical data of patients with psoriatic arthritis(Ps A)were analyzed to explore the TCM syndrome characteristics of Ps A,as well as the correlation between syndrome type and patients’ general information,clinical symptoms,laboratory examination,imaging examination,etc.,so as to provide reference for the clinical application of TCM syndrome differentiation and treatment of Ps A.Methods: A retrospective study was conducted to collect the case data of Ps A patients hospitalized in Liaoning university of traditional Chinese medicine affiliated hospital from January 2013 to December 2018.The data were screened in accordance with the admission standards.A database was created using Excel software,and SPSS 24.0 was used for data analysis to explore the characteristics of Ps A TCM syndromes.Results: 1.A total of 101 cases were collected in this study,with a male to female ratio of 1:1.46.The mean age was 54.09±10.56 years,and the mean course of disease was 75.99±70.50 months.2.Syndrome distribution(in order of proportion): syndrome of dampness and heat(31.68%),syndrome of deficiency of liver and kidney(29.71%),syndrome of blood heat and dryness(17.82%),syndrome of wind chill blocking collaterals(10.89%),and syndrome of heat poisoning(9.90%).3.The difference between the course of disease of the traditional Chinese medicine syndrome was statistically significant(P>0.05),and the length of course is in order as follows: syndrome of deficiency of liver and kidney > syndrome of dampness and heat > syndrome of heat poisoning > syndrome of blood heat and dryness > syndrome of wind chill blocking collaterals.4.Clinical manifestation:(1)The differences in PASI between each TCM syndrome group were statistically significant(P < 0.05),and the severity of skin damage was in the order of : syndrome of dampness and heat > syndrome of blood heat and dryness > syndrome of heat poisoning > syndrome of deficiency of liver and kidney > syndrome of wind-chill blocking collateral.(2)The difference of heel pain between each TCM syndrome group was statistically significant(P< 0.05),and the highest proportion of patients with heel pain was found in the deficiency of liver and kidney.(3)There were no statistically significant differences in the number of joint tenderness,number of joint swelling,morning stiffness,lumbago and back pain,and nail changes among the TCM syndrome groups(P > 0.05).5.Laboratory examination and imaging examination:(1)The differences of the CRP between each TCM syndrome group were statistically significant(P< 0.05),and the level of CRP was in order of: syndrome of dampness and heat >syndrome of deficiency of liver and kidney >syndrome of heat poisoning >syndrome of wind-chill blocking collateral> syndrome of blood heat and dryness.(2)The differences of the ESR between each TCM syndrome group were statistically significant(P< 0.05),and the level of ESR was in order of: syndrome of dampness and heat >syndrome of heat poisoning >syndrome of deficiency of liver and kidney> syndrome of blood heat and dryness >syndrome of wind-chill blocking collateral.(3)The differences of the blood uric acid between each TCM syndrome group were statistically significant(P< 0.05),and the level of blood uric acid was in order of: syndrome of dampness and heat >syndrome of heat poisoning >syndrome of deficiency of liver and kidney> syndrome of blood heat and dryness >syndrome of wind-chill blocking collateral.(4)The differences of PLT,globulin,HLA-B27,the joints of ultrasonic,hands X-ray and CT of the sacroiliac joint were not statistically significant(P > 0.05).6.Among the 101 cases included in the study,17.82% of the patients had hyperuricemia(HUA),with a male to female ratio of 1.57:1.The percentage of HUA in each group was syndrome of dampness and heate(28.13%),syndrome of heat poisoning(20.00%),syndrome of deficiency of liver and kidney(13.33%),syndrome of blood heat and dryness(11.11%),and syndrome of wind chill blocking collaterals(9.09%).There was no statistically significant difference in age and course of disease in each TCM syndrome group(P > 0.05).There were no statistically significant differences in PASI,number of joint tenderness,number of joint swelling,morning stiffness time,lumbago back pain,heel pain and nail changes in each group(P > 0.05).There were no statistically significant differences in ESR,PLT,globulin,HLA-B27,the joints of ultrasonic,hands X-ray and CT of the sacroiliac joint in each group(P > 0.05).The difference of CRP between non-combined HUA and combined HUA group in the syndrome of dampness and heat group was statistically significant(P < 0.05).The difference of CRP between non-combined HUA and combined HUA group in the syndrome of heat poisoning group was statistically significant(P < 0.05).Conclusion: 1.The syndrome of dampness and heat accumulate in TCM is the most common,and the course of syndrome of deficiency of liver and kidney is longer than other TCM syndromes.2.The syndrome of dampness and heate and syndrome of blood heat and dryness had severe psoriatic sign.The syndrome of deficiency of liver and kidney often suffer from heel pain.3.The disease activity and blood uric acid level was higher in patients with syndrome of dampness and heate,syndrome of heat poisoning and syndrome of deficiency of liver and kidney.4.The disease activity of Ps A+HUA group was higher than the Ps A+NUA group. |
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