The Clinical Value Of Peripheral Blood Eosinophils In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective In this study,according to different levels of eosinophils in peripher al blood of patients with acute exacerbation of chronic obstructive pulmonary d isease(AECOPD),infection during hospitalization,length of stay,treatment res ponse to glucocorticoid,and mortality after discharge were compared to evaluat e its clinical value in AECOPD.Methods A total of 105 patients with AECOPD who were hospitalized in the Department of Respiratory and Critical Care Medicine of the Third Affiliated Hospital of Anhui Medical University were selected as the research subjects,collect all the patients’ age,gender,history,smoking history,chronic obstructive pulmonary disease(copd)assessment test(CAT)questionnaire,complications,etc.,Serum procalcitonin(PCT),C-reactive protein(CRP),routine EOS% and WBC were collected after admission.Lung function parameters,exhaled nitric oxide(Fe NO),hospital stay,hormone usage and days,etc.The frequency of acute exacerbation and mortality were followed up.According to the EOS% level at admission,46 cases were in the high level group(EOS% > 2%)and 59 cases were in the low level group(EOS%≤2%).The differences of general information,use of glucocorticoid,length of hospital stay,frequency of acute exacerbation within 1 year and fatality rate between the two groups were analyzed.Results There were no significant differences in age,gender,COPD course,smoking history,CAT score,body mass index(BMI),complications,FEV1/FVC,and the percentage of forced breathing volume in one second in the predicted value(FEV1%)between the two groups(P > 0.05).WBC,CRP and PCT in high level group were lower than those in low level group,and Fe NO value was higher than that in low level group,the difference was statistically significant(P < 0.05).Relationship between EOS% and Fe NO before treatment: there was a positive correlation between EOS%and Fe NO(r=0.183,P=0.031).There was no significant difference in the total time of glucocorticoid use,the dose of nebulizing hormone use and the time of inhaling hormone between the two groups during hospitalization(P > 0.05).The duration and dose of intravenous hormone in the high level group were lower than those in the low level group,and the differences were statistically significant(P < 0.05).There was no significant difference in the frequency of exacerbations and case fatality rate between the two groups within 1 year after discharge(P > 0.05).The length of hospital stay in the high level group was shorter than that in the low level group,and the difference was statistically significant(P < 0.05).Conclusion The peripheral blood eosinophil has important clinical value in helping to judge the condition of AECOPD patients,guiding hormone therapy and evaluating the prognosis.