Eosinophils Count In Peripheral Blood And Detection Of Exhaled Nitric Oxide For Predicting The Effect Of Inhaled Corticosteroid In Patients With Stable Chronic Obstructive Pulmonary Disease

Objective: To investigate the predictive value of the eosinophils(EOS%)count in peripheral blood and detection of fraction of exhaled nitric oxide(FeNO)for predicting the effect of inhaled corticosteroid in stable chronic obstructive pulmonary disease(COPD).Methods: From June 2017 and December 2017,a total of 39 patients who were diagnosed COPD in the First Affiliated Hospital of NanChang University respiratory clinic were enrolled in the study,the value of EOS%,FENO,pulmonary function indicators(including FVC,FEV1,PEF)and CAT score were decteded and recorded.COPD patients were given Budesonide(400ug,twice a day),the phlegm,cough and other basic treatment were given at the same time.After 4 weeks,all of the examines were repeats.After 4 weeks of treatment,increase in FEV1?200ml and or the CAT score reduce ?2 point were defined ICS response group,the others were defined no ICS response group.The paired t-text,Pearson correlation coefficient,the independent sample t-test and ROC curve analyses were performed,a value of P<0.05 was considered statistically significant.Results: The significant differences were observed in EOS%,FeNO,FVC,FEV1,PEF and CAT score between pretherapy and post-treatment(P<0.001).The baseline value of EOS% had not significant correlation with the baseline value of FVC,FEV1,PEF and CAT score.The baseline value of FeNO had significant correlation with the baseline value of CAT score(r=0.753,P < 0.001),but had not significant correlation with FEV1,FVC and PEF.The baseline value of EOS and FeNO had not significant correlation with the improvement of FVC,FEV1 and PEF after 4 weeks of treatment,but had significant correlation with the improvement of FEV1(r=0.376;r=0.351).The AUC of using the baseline value of EOS% and FeNO to diagnose responders and non-responders were 0.557 and 0.718 respectively.Conclusion: In stable COPD patients,the baseline value of FeNO can predict the effect of inhaled corticosteroid,but EOS% can't.