| Objective:Exploring the correlation between body composition indicators and bone mineral density in postmenopausal type 2 diabetes mellitus(T2DM)patients,in order to identify the potential risk factors of Diabetic osteoporosis(DOP)and provide reference for the prevention and treatment of diabetic osteoporosis.Methods:A total of 216 postmenopausal T2 MD patients(amenorrhea > 1 year)hospitalized in the Department of Endocrinology of our hospital from July2020 to March 2021 were selected according to the inclusion and exclusion criteria and included in the study.General information of patients was recorded,including name,age,menopausal age,course of diabetes,previous history,medication history,height,weight and other basic information.At the same time,recorded the patient’s fasting blood glucose(FBG),glycosylated hemoglobin(Hb A1c),total cholesterol(TG),triglycerides(TC),low-density lipoprotein(LDL),high-density lipoprotein(HDL),alanine aminotransferase(ALT)),aspartate aminotransferase(AST),blood creatinine(Cr),thyroid function(FT3,FT3,TSH)and other laboratory indicators.All enrolled patients underwent bone density testing,and measured body composition and visceral fat area under fasting conditions,and recorded fat mass(FM),lean mass(LM),and bone mineral content(Bone mineral content,BMC),Fat free mass(FFM),body fat rate,Android/Gynoid(A/G),lumbar and femoral neck Bone mineral density(BMD),visceral fat area and other inspection indicators.According to the 1994 WHO diagnostic criteria for osteoporosis,The T value ≥-1 SD was divided into T2 MD normal bone mass group(44cases),-2.5SD < T value<-1 SD was divided into T2 MD osteopenia group(89 cases),and T value ≤-2.5SD into T2 MD combined with osteoporosis group(83 cases).To evaluate whether there were statistical differences in basic information and body composition,SPSS 25.0 software was used for statistical processing.Continuous measurement data following normal distribution are expressed as mean±standard deviation,while measurement data of skewness distribution are expressed as median(interquartile range).Analysis of variance was used for comparison between groups.Rank sum test was used for measurement data that did not follow normal distribution and had uneven variances.Pearson correlation analysis was used when both bivariates were continuous measurement data with normal distribution,while Spearman correlation analysis was used to analyze the correlation between variables with unnormal distribution.Potential influencing factors were analyzed by univariate regression,and independent influencing factors for osteoporosis were included in multivariate Logistic regression analysis for univariate significant variables.P<0.05 was considered statistically significant.Results:1.The prevalence of osteoporosis in type 2 diabetes was 38.43%.In the postmenopausal T2 MD patients,compared with the normal bone mass group,the osteopenia group and the osteoporosis group are older and have a longer course of diabetes.For BMI,LM,FM,FFM,lumbar spine L1-4 BMD and femoral neck BMD,the osteopenia group and the osteoporosis group were lower than the normal bone mass group.2.With the increase of age,BMC and LM of postmenopausal T2 MD patients showed a decreasing trend,while body fat percentage(%)showed an increasing trend.3.With the decrease of LM,BMC and FFM,the BMD of lumbar spine and femoral neck BMD also decreases.4.The age of postmenopausal T2 MD patients was negatively correlated with lumbar spine and femoral neck BMD,and the course of diabetes were negatively correlated with femoral neck BMD.TG,LM,BMC and FFM were positively correlated with lumbar spine and femoral neck BMD.5.Age was an independent risk factor for osteoporosis,and LM was an independent protective factor for osteoporosis in T2 MD patients.Conclusion:1.Osteoporosis associated with T2 MD is common.With the increase of age,BMC and LM of postmenopausal T2 MD patients showed a decreasing trend,while body fat percentage(%)showed an increasing trend.2.With the decrease of LM,BMC and FFM,the BMD of lumbar spine and femoral neck BMD also decreases.3.Age and duration of diabetes in postmenopausal T2 MD patients were negatively correlated with lumbar and femoral neck BMD,while BMI,LM and BMC were positively correlated with lumbar and femoral neck BMD.4.Age is an independent risk factor for T2 MD associated with osteoporosis,and LM is an independent protective factor for T2 MD associated with osteoporosis. |
