Relationship Between Chronic Kidney Disease Hypertension,Renal Function Status,Chronic Glomerulopathy And Renal Ultrasound Measurements

Objective:To explore the relationship between hypertension,renal function status,chronic glomerular disease score and renal ultrasound measurement of chronic kidney disease,and to evaluate renal function and chronic glomerular chronicity through noninvasive ultrasound examination and blood pressure status Provide a basis for the degree of pathological damage.Methods:From January 2018 to October 2019,a total of 295 patients under 40 years of age were diagnosed as CKD at the Department of Nephrology,the First Affiliated Hospital of Xiamen University.The maximum length,width,thickness,and cortical thickness of the coronal plane of the kidneys of the patients are measured by ultrasound,the kidney volume is calculated using the two-dimensional volume formula of the kidney and the body surface area is used for correction,and the length of the kidney is corrected by height;Doppler ultrasound measures the kidney The maximum blood flow velocity(Vs)of the interlobar artery and the end diastolic blood flow velocity(Vs)are calculated,and the resistance index(RI)is calculated;patients under 18 years old use Schwarts modified formula to calculate eGFR,adults use CKD-EPI Scr formula Calculate eGFR,perform CKD staging according to the guidelines of the American Kidney Disease Foundation,and divide it into groups with hypertension and no hypertension according to blood pressure;refer to the Katafucchi semi-quantitative method to integrate chronic glomerulopathy;analyze the morphological indicators of the kidney,Correlation between hemodynamic changes,renal function status,chronic glomerular lesion score and hypertension complications.Results:1.In the CKD1-5 stage,the incidence of hypertension was 16.1%,39.1%,12.2%,86.7%,100%,P<0.05.2.In each stage of CKD1-3a,the corrected kidney in the hypertension group Compared with the non-hypertensive group,the volume,length,and thickness of the renal cortex were significantly reduced,and the interlobar artery RI value increased,P<0.05.After correction,the kidney volume gradually shrank and the RI value gradually increased,P<0.05.4.Hypertension,CKD stage or eGFR had a significant correlation with the score of chronic glomerular disease in CKD patients.0.402,0.471,-0.518,but the volume and length of the kidney and the thickness of the renal cortex after correction were not significantly related to the chronic glomerular lesions.Conclusion:1.In general,as CKD progresses or eGFR decreases,the incidence of hypertension complications gradually increases.After correction,the kidney volume and length gradually decrease,and the RI value gradually increases.2.In the same clinical stage of early CKD,younger patients with hypertension have lower kidney volume,diameter,and cortical thickness after correction than those without hypertension,and RI is higher than those without hypertension.3.Hypertension,CKD stage,or eGFR have a significant correlation with the score of chronic glomerular disease in CKD patients.