Calculation Of Glucosyltransferase(ALG8) Regulating Human Left Brain Cognitive Network

This paper constructs a molecular and knowledge computing network for feedback/upstream/downstream activation and inhibition of human left brain glucosyltransferase(ALG8),which is closely related to cognition and integrates GRNInfer and DAVID.Based on the shared knowledge of ALG8 feedback/upstream/downstream activation and inhibition of different molecules,a new system mechanism for ALG8 to regulate human left brain cognition is proposed and verified by multiple subnets as follows:Integrate ALG8 upstream inhibition,feedback inhibition,downstream inhibition of Huntington's disease,and its upstream inhibition of respiratory electron transport chain|Calcium signal transduction pathway|Nucleotide binding exists in NR1D2?2,PRKCI?1,TUBGCP4?1,KCNK1,VDAC2,TULP3,NDUFA5,TUBGCP4?2 CGRRF1 subnet;or feedback inhibition of blood coagulation exists in KIF3A,MAP1B?1,MAP1B?2,CAMTA1,SERINC3 subnet;or downstream inhibition of substantia nigra development |cell metabolism process| phototransduction of visible light,calcium signal transduction pathway,calcium regulation of heart cells,G protein signal transduction plasma membrane | Positive regulation of GTPase activity and insulin secretion exist in WDR68,PCTK2,CALM1,GTF2I?1,U00928,AL050030 subnets.ALG8 positive self feedback inhibition of Huntington's disease,through its upstream inhibition of respiratory electron transport chain|calcium signal transduction pathway |nucleotide binding| blood coagulation |substantia nigra development| cell metabolism | light transduction | visible light | insulin secretion affect cognition and positive verification.ALG8 positive self feedback activated enzyme binding,phagosome negative validation.Mutual verification with upstream and feedback activation,upstream and downstream inhibition of small GTPase mediated signal transductionThrough the negative self feedback activation or inhibition network of ALG8,we propose that ALG8 speed limiting RAS signal transduction pathway,hippo signal transduction pathway,poly(a)RNA binding,protein domain specific binding,protein stability,and protein transport are negatively verified.In conclusion,the new systematic analysis of ALG8 in this paper adds new content to the cognitive theory and application of human left brain,and provides important theoretical basis and application value for the study of cognitive mechanism of human left brain.