| Purpose. To examine ability of collagen solution (CS) to aid revascularization of necrotic infected root canals in immature dog teeth. Sixty immature teeth (6 dogs) were infected, disinfected and randomized into experimental groups: (1) no further treatment; (2) blood in canal; (3) CS in canal; (4) CS+blood; (5) negative controls (natural development). Uncorrected Chi-squared analysis of radiographic results showed no statistical differences (p≥0.05) between experimental groups regarding healing of radiolucencies or radicular thickening; however, group 2 showed significantly more apical closure than group 1 (p=0.01). There were no statistical differences between experimental groups for histological results. Groups 1-4 (previously infected) showed positive radiographic outcomes (thickened walls in 35.4%, apical closure in 54.9%, healing radiolucencies in 65.9%) and histologic outcomes (thickened walls in 43.9%, apical closure in 54.9%, new luminal tissue in 29.3%). A collagen solution did not aid revascularization of disinfected immature dog root canal systems, but revascularization is possible. |
