Clinical Observation Of Jianpi Xiaopi Decoction Combined With Umbilical Application In The Treatment Of FD (postprandial Malaise Syndrome) Syndrome Of Spleen Deficiency And Qi Stagnation

Objective:To observe the clinical efficacy of Jianpi Xiaopi Decoction combined with umbilical cord in the treatment of FD(postprandial discomfort syndrome)spleen deficiency qi stagnation syndrome and the changes of plasma Ghrelin and CCK and further explore its curative effect mechanism.Methods:A total of 60 patients who met the criteria for inclusion of FD(postprandial discomfort syndrome)spleen deficiency qi stagnation syndrome were divided into treatment group and control group according to the random principle.The treatment group was treated with Jianpi Xiaopi Decoction combined with umbilical cord method,and the control group was treated with oral mosapride citrate dispersible tablets.All patients were treated for 4 weeks.All patients underwent TCM symptom scores and plasma Ghrelin and CCK before and after treatment.After the treatment,the TCM symptom scores,clinical efficacy,plasma Ghrelin,CCK levels and adverse reactions were compared between the two groups.Observe and compare.Results:(1)Comparison of clinical efficacy:After 4 weeks of treatment,the total effective rates of the treatment group and the control group were 93.3%and 80.0%;respectively.The total effective rate of the two groups was compared,and the difference was statistically significant(P<0.05).It indicated that the treatment group was better than the control group.(2)TCM symptom score comparison:After 4 weeks of treatment,the TCM symptom scores of the treatment group were significantly different from those before treatment(P<0.05);the control group had less food,poor stool and syndrome There was no significant difference between the two groups(P>0.05).The other symptom scores were statistically significant(P<0.05).After treatment,the difference between the two groups was statistically significant(P<0.05),indicating that the treatment group was better than the control group in improving TCM symptom scores.(3)Comparison of plasma ghrelin and CCK levels:After 4 weeks of treatment,plasma Ghrelin and CCK levels were compared between the two groups(P<0.05),and there were statistical differences it indicated that both the treatment group and the control group can improve the plasma levels of Ghrelin and CCK in patients.moreover,the treatment group was better than the control group in improving the levels of plasma Ghrelin and CCK in patients.(4)Observed patient safety indicators:no adverse reactions occurred in either group.Conclusions:Jianpi Xiaopi Decoction combined with umbilical cord treatment for postprandial discomfort syndrome(spleen deficiency and qi stagnation syndrome)is effective,and has obvious advantages in clinical efficacy and symptom improvement compared with the control group.The therapeutic mechanism may be related to the regulation of plasma Ghrelin and CCK.The change is related.