Clinical Observation On The Pathological Characteristics Of Traditional Chinese Medicine And Risk Factors In Non-alcoholic Fatty Liver Disease

Objective:1.To characterize the Traditional Chinese Medicine pathologic features of Non-alcoholic fatty liver disease (NAFLD);2. To study risk factors such as sex, IR, serum glucose and lipid metabolic status of Traditional Chinese medicine pathological changes of NAFLD.Methods:Data from225NAFLD patients and200Healthy Controls were analyzed to characterize the Traditional Chinese Medicine pathologic features of NAFLD, with syndrome element differentiation method; explore the risk factors of Traditional Chinese medicine pathological changes of NAFLD.Results:1. HbAlc, TG,2hPBG, FINS,HOMA-IR in NAFLD group is higher than the control group (P<0.01); HDL-C, LDL-C in the control group is higher than NAFLD group (P <0.01).2. The Traditional Chinese medicine pathologic features of NAFLD,the niduses of NAFLD are mainly located in spleen (51.6%) and liver (67.1%); the sthenia-syndrome mainly consists of phlegm (93.8%), damp (92.0%) and hot (61.3%); the asthenia-syndrome mainly consists of Yin deficiency (77.8%), blood deficiency (63.1%) and Qi deficiency (61.3%).3.The incidence at spleen, kidney, liver and uterus niduses was higher in female than in male, so does the occurrence of blood stasis, Yang deficiency, blood deficiency Qi deficiency and essence deficiency(P<0.01).The integral of damp, Phlegm and Qi stagnation was higher in female than in male(P<0.05).The incidence at kidney,spleen, qi stagnation,qi deficiency, yang deficiency, xue deficiency increased with age(P<0.05); The integral of kidney,liver, qi stagnation,qi deficiency, yang deficiency, xue deficiency and blood stasis increased with age(P<0.05). 4. The risk factors of NAFLD, Accompanied by the emergence of liver,spleen, uterus, damp,Phlegm, qi stagnation and xue deficiency, the incidence of NAFLD were increased. As the TG and the TC increased, the incidence of NAFLD were increased0.519,1.7times. Accompanied by an increase in the LDL-C, the incidence of NAFLD may be reduced.5. Accompanied by increased of the LDL-C,the HOMA-IR and age, the incidence of kidney syndrome were increased,while accompanied by increased of the muscle mass and the2hPBQ the incidence of kidney syndrome was reduce. Accompanied by increased of age and the emergence of female, the incidence of spleen, xue deficiency and qi stagnation syndrome were increased.Accompanied by increased of the2hPBG and the emergence of female, the incidence of liver syndrome and blood stasis were increased.Accompanied by increased of the BMI and the AST, the incidence of damp syndrome were increased.Accompanied by increased of the2hPBG, the incidence of hot syndrome were increased.Accompanied by increased of the2hPBG and the AST, the incidence of yin deficiency syndrome were increased,while accompanied by increased of the ALT, the incidence of yin deficiency syndrome were reduce.Conclusions:1. The feature of NAFLD is intermingled deficiency and excess, NAFLD niduses are mainly located at spleen and liver. the pathological of traditional Chinese Medicine was mainly consists of phlegm, damp,hot,yin deficiency,blood deficiency and Qi deficiency.2. Uterus is one of the niduses of female patients with NAFLD.3.Kidney syndrome in patients with NAFLD and the IR,the LDL-C are reciprocal causation,if the IR and the LDL-C are increased,it demonstrate that the disease location may be in the kidney. The BMI and damp syndrome are reciprocal causation,the patient with obesity may receive damp syndrome.The Traditional Chinese Medicine pathologic features of NAFLD patients with impaired glucose regulation may be liver depression and qi stagnation,yin deficiency and endogenous hotness,and blood stasis.The relationship of the Traditional Chinese Medicine pathologic features of NAFLD and the liver enzyme index,the body fat need to make clear in further study.4. Abnormity of blood lipid metabolic is a risk factor which can cause NAFLD. The IR and abnormal glucosr affecting the occurrence of NAFLD.