Related Research On Risk Factors Of Type 2 Diabetic Retinopathy And TCM Syndromes

Purpose:In this study,the medical records of type 2 diabetic patients were collected and then analyzed by retrospective method to study the related risk factors and syndrome characteristics of DR in TCM.Material and method:The medical records were selected from the patients who has a clear diagnosis of type 2diabetes and ophthalmology consultation in Liaoning University of Traditional Chinese Medicine Affiliated Hospital from November 2015 to June 2016.According to the ophthalmology diagnosis,the patients were divided into DR group and NDR group.The gender,age,smoking history,drinking history,HbA1c,hypertension,BMI,TC,LDL-C,HDL-C,TG,UA,GFR,mAlb,UCr and other related indicators to explore the related risk factors and their relationship between the two groups;Afterwards,patients in DR group were diagnosed according to TCM syndrome diagnostic criteria to further analyze the distribution characteristics of DR syndrome.Results:1.Comparing the data between DR group and NDR group,the differences of the duration of DR,HbA1c,BMI,TG,TG/HDL-C,mAlb,UAE,are significant(P<0.05).2.Spearman analysis results suggest that the duration of DR,HbA1c,BMI and TG/HDL-C are positively correlated with diabetic retinopathy eye level.3.Logistic analysis shows that the duration of DR,HbA1c,BMI(B>0,OR>1 and P<0.05)are the risk factors of diabetic retinopathy.4.The single syndrome analysis suggest that Qi deficiency syndrome,Yin deficiency syndrome,liver deficiency syndrome,phlegm syndrome,blood stasis syndrome appear higher frequency in DR group.Further X~2 analysis shows that in early diabetic retinopathy(phase?,?)there are less Yang deficiency syndromes.With the progressing of DR eye disease,the frequency of Yang deficiency syndromes also increases;phase?has less liver deficiency syndrome,With the progression of DR eye disease,the frequency of liver deficiency syndrome also increases.Combine syndromes analysis suggests that most of patients in DR group are with three combine syndromes(30%)and all syndromes are combination of Xu and Shi syndromes.Conclusion:1.In T2DM,the occurrence of DR is not related to the age,sex,smoking history,alcohol drinking history,hypertension,low density lipoprotein,high density lipoprotein,cholesterol,glomerular filtration rate and serum uric acid level.2.The sick years,HbA1c,BMI,TG,TG/HDL-C,mAlb,UAE are all associated with the occurrence of type 2 diabetes.The higher of the sick years,HbA1c,BMI,the TG/HDL-C,the worse phase of diabetic retinopathy.3.The sick years,HbA1c,BMI are three related factors of DR in T2DM.4.Qi deficiency syndrome,Yin deficiency syndrome,Liver deficiency syndrome,phlegm syndrome,blood stasis syndrome appear higher frequency.The pathological features of the DR can also be roughly summarized as the coexistence of deficiency and excess.5.The frequency of Liver deficiency syndrome,Yang Deficiency syndrome in the early diabetic retinopathy are less,with the progression of DR,they occur and the proportion gradually increased.6.In this study,the frequency of the Liver deficiency syndrome>the Kidney deficiency syndrome>the Spleen deficiency syndrome,so the sick viscera mostly in the liver,spleen and kidney three viscera,and the eyes are related in DR.