Evaluation Of The Curative Effect And Quality Of Life Of The Traditional Chinese Medicine Wenyang Huayu Granules On Patients With Coronary Heart Disease Complicated By Bradyarrhythmia

Purpose:To observe the clinical effect and quality of life improvement of patients with coronary heart disease with slow arrhythmia by dispelling phlegm and eliminating stasis granule,and to provide clinical scientific basis for the further research and application of this drug.Material and method:A total of 60 patients with coronary heart disease with slow arrhythmia were included in this study,the syndrome differentiation of these patients is deficiency of the heart-yang and phlegm-stasis syndrome.According to the random number table,they were randomly divided into basic western medicine group(the western medicine group),basic western medicine+dispelling phlegm and eliminating stasis granule group(combined group),30 patients in each group,the course was 4 weeks.The 24-hour dynamic electrocardiogram,quality of life assessment,and TCM symptom scores were used as evaluation indicators to observe its clinical efficacy and improvement of quality of life.Results: 1.Comparison of baseline indexes in the two groups of patients before treatment showed no difference in statistical results(P>0.05),which was comparable.2.Heart rate effect: Before treatment,two groups of patients with dynamic electrocardiogram heart rate index comparison,there is no statistical difference(P>0.05).After treatment,there was no significant change in heart rate indexes of patients in the western medicine group(P>0.05);In the combined group,the slowest heart rte and the average heart rate were both increased,and were significantly better than those in the western medicine group(P<0.05).3.The improvement of ST-T segment depression and T wave inversion on dynamic electrocardiogram: The total effective rate of the western medicine group was 40%,the total effective rate of the combined group was 68%.Among the two groups compared,P<0.05.4.Comparison of curative effect of TCM symptoms: The total effective rate of the western medicine group was 37%,the total effective rate of the combined group was 77%.Among the two groups compared,P<0.05.5.Comparison of TCM symptom score: Before treatment,there was no statistically significant difference between the two groups in the total score of TCM symptoms(P>0.05).After treatment,the total score of TCM symptoms in the combined group was more significant than that in the western medicine group(P<0.05).6.Comparison of quality of life improvement:Before treatment,there was no significant difference between the two groups of patients in the Seattle angina questionnaire.After treatment,both groups showed improvement in the four dimensions of physical limitation,angina stability,angina frequency,and treatment satisfaction(P<0.05).There was no significant change in disease perception between the two groups(P>0.05).In the two dimensions of physical limitation and angina frequency,the efficacy of the combined group was more significant than that of the western medicine group(P<0.05).7.Safety evaluation: There were no significant changes in the routine indexes of blood routine,liver function,renal function,urine routine and stool routine before and after treatment in the two groups(P>0.05).The patients in each group had good tolerance,no obvious adverse reactions occurred,and the clinical application was safe.Conclusion:Dispelling phlegm and eliminating stasis granule combined with western medicine conventional drugs in the treatment of coronary heart disease with slow arrhythmia can effectively improve the patient's heart rate,improve myocardial ischemia,reduce the patient's clinical symptoms and improve quality of life,and no toxic side effect,clinical application is safe and effective.It is worth popularizing.