Study On The Difference Of Cardiac Function And Quality Of Life Between Patients With Partial Phlegm And Blood Stasis Syndrome Of Heart Failure Of Coronary Heart Disease And Patients With Intermingled Phlegm And Blood Stasis Syndrome

Objective:This study aimed at the patients with partial phlegm and blood stasis syndrome of heart failure of coronary heart disease in patients with Intermingled phlegm and blood stasis,comparative cardiac function,physical and chemical indicators and quality of life Heart failure in coronary heart disease,to provide evidence for the intervention and treatment of Heart failure in coronary heart disease with traditional Chinese medicine.Methods: 120 patients with heart failure and Intermin gled phlegm and blood stasis syndrome of coronary heart disease were divided into two groups according to TCM syndrome differentiation criteria.,60 cases in partia l stasis group and 60 cases in partial phlegm group,Cardiac function was graded according to NYHA standard.The differences of cardiac function,severity of angin apectoris,physical and chemical indexes and quality of life between the two groups were compared.Results: 1.General data comparison between the two groups: There was no significant difference in age,height,weight,BMI,systolic blood pressure and diastolic blood pressure between the two groups(P > 0.05).2.Comparison of blood biochemical indexes between the two groups: 3.Comparison of cardiac color Doppler ultrasound indexes between the two groups:The left ventricular short axis shortening rate(FS)in the partial stasis group was lower than that in the partial phlegm group,and the difference was statistically significant(p < 0.01).4.Comparison of quality of life scores of angina pectoris and heart failure between the two groups:(1)Seattle angina pectoris(SAQ)score comparison: there were significa nt differences between the partial stasis group and the partial phlegm group in the degree of restriction of physical activity,stable state of angina pectoris,attack of angina pectoris and disease awareness(P < 0.01),and the partial stasis group was significantly more important than the partial phlegm group.(2)Minnesota Heart Failure Quality of Life(LiHFe)score comparison: the quality of life in the partial stasis group was significantly different from that in the partial phlegm group(p< 0.01),and the partial stasis group was significantly more serious than that in the partial phlegm group.5.Comparison of different cardiac functions of the same syndrome type:(1)Comparisons between patients with Grade III of cardiac function and patients with Grade II of cardiac function in the partial stasis group:1)NT-proBNP and coagulation function index: NT-proBNP,prothrombin time(PT)and activated par tial thromboplastin time(APTT)of patients with grade III cardiac function in the partial stasis group were higher than those of patients with grade II cardiac function,and the difference was statistically significant(P < 0.05).2)Comparison of cardiac color Doppler ultrasound indexes between the two groups: the left ventricular short axis shortening rate(FS)of grade II of cardiac function in patients with partial stasis was higher than that in patients with grade III of cardiac function(p < 0.05).(2)Comparison of patients with grade III cardiac function and patients with grade II cardiac function in partial phlegm group:1)NT-proBNP and coagulation funct ion index: PT and APTT of patients with grade III cardiac function in partial phlegm group were higher than those of patients with grade II cardiac function,and the difference was statistically significant(P < 0.05).2)Comparison of cardiac color Doppler ultrasound indexes between the two groups:The left ventricular short axis shortening rate(FS)and left ventricular ejection fraction(EF)in patients with partial phlegm were higher than those in patients with cardiac function grade III,and there were significant differences(P < 0.01).6.Comparison of the same cardiac function in different syndromes:(1)Comparison of cardiac function grade II between partial stasis group and partial phlegm group:1)Comparison of biochemical indicators:the glycosylated hemoglobin(GHB)of patients with grade II cardiac function in the partial stasis group was lower than that of patients with grade II cardiac function in the partial phlegm group,and the difference was statistically significant(p <0.05).2)Comparison of cardiac color Doppler ultrasound indexes between the two groups:The left ventricular short axis shortening rate(FS)of the patients with grade II cardiac function in the partial stasis group was lower than that of the patients with grade II cardiac function in the partial phlegm group,and the difference was significant(p < 0.01).3)The quality of life scores of angina pectoris and heart failure between the two groups were compared:(1)Seattle Angina Pectoris Score: There were significant differences between the partial stasis group and the partial phlegm group in terms of physical activity limitation,angina attack and disease awar eness(P < 0.01),and the partial stasis group was significantly more important than the partial phlegm group.(2)Comparison of Minnesota Heart Failure Quality of Life Score: There was a significant difference in grade II quality of life of cardiac function between the partial stasis group and the partial phlegm group(p < 0.01),and the partial stasis group was significantly heavier than the partial phlegm group.(2)Comparison of cardiac function grade III between partial stasis group and partial phlegm group:1)Comparison of biochemical indicators: ApoAI of patients with grade III cardiac function in partial stasis group was lower than that of patients with grade III cardiac function in partial phlegm group,and the difference was statistically significant(p < 0.05).2)Comparison of cardiac color Doppler ultrasound indexes between the two groups: Left ventricular short axis shortening rate(FS)and left ventricular ejection fraction(EF)of patients with grade III of cardiac function in the partial stasis group were lower than those of patients with grade III of car diac function in the partial phlegm group,and the difference was statistically signif icant(p < 0.05).3)The quality of life scores of angina pectoris and heart failure between the two groups were compared:(1)Seattle Angina Pectoris Score: There were significant differences in physical activity limitation,angina pectoris attack and disease recognition between the partial stasis group and the partial phlegm group(all P < 0.01).The partial stasis group had significantly higher heart function class III than the partial phlegm group.(2)Comparison of Minnesota Heart Failure Quality of Life Score: There was significant difference between the heart function grade III quality of life in the partial stasis group and the heart function grade III in the partial phlegm group(p < 0.01).The heart function grade III in the partial stasis group was significantly heavier than the heart function grade III in the partial phlegm group.Conclusion:1.The coagulation function and EF index of cardiac function in patients with partial stasis were lower than those in patients with partial phlegm,while NT-proBNP in patients with partial stasis was higher than that in patients with partial phlegm,suggesting that patients with partial stasis had higher risk ofthrombosis and worse cardiac function.2.The disorder of glucose and lipid metabolism in partial phlegm group was more obvious than that in partial stasis group.3.The higher the grade of cardiac function,the higher NT-proBNP and the lower EF,suggesting the severity of heart failure.4.The degree of restriction of physical activity,stable state of angina pectoris and attack of angina pectoris in patients with partial stasis were more serious than those in patients with partial phlegm.The quality of life score of the patients with partial phlegm was higher than that of the patients with partial phlegm,suggesting that the quality of life of the patients with partial phlegm was worse than that of the patients with partial phlegm.