| Objective:This study was to the observe effect of Chang Zhou Tong Bian decoction on constipation patients with deficiency of both Qi and Yin,and randomly compared it with Qi Rong Run Chang Oral Liquid,which was recommended by Consensus opinions of TCM experts on the diagnosis and treatment of constipation(2017)for the treatment of constipation with deficiency of both Qi and Yin.To provide objective and real basis for the curative effect of Chang Zhou Tong Bian decoction in treating constipation of Qi-Yin deficiency type,and to provide an effective guidance for clinical treatment of constipation of Qi-Yin deficiency type.At the same time,to inherit Professor Tutor's rich experience in treating constipation of Qi-Yin deficiency type,to sort out its clinical medication characteristics and formulation ideas.Methods:From May 2018 to December 2018,60 patients with constipation of deficiency of both Qi and Yin were randomly divided into Chang Zhou Tong Bian decoction group(observation group)and Qi Rong Run Chang Oral Liquid group(control group),30 cases in each group.The study period was 7 weeks,including 3 weeks of continuous treatment,4 weeks of follow-up.From the 2nd day of admission,the observation group took Chang Zhou Tong Bian decoction,which was decocted by the decoction room of The Hospital,Chinese Academy of Chinese Medical Sciences,twice a day,and the control group took Qi Rong Run Chang Oral Liquid 20 ml each time,three times a day.During the study,the data of constipation symptoms and curative effect score,TCM syndrome score,quality of life score,number of spontaneous complete defecation per week and adverse reactions were recorded in detail before treatment,after 3 weeks treatment,4 weeks after withdrawal of drugs.The case observation form was filled in accurately and timely.After all cases were observed,SPSS 20.0 was used to analyze the data and draw a conclusion.Result:Sixty constipation patients with deficiency of both Qi and Yin were included in this study.Among them,there were 30 cases in the observation group,4 males and 26 females;30 cases in the control group,7 males and 23 females,and statistical analysis showed no statistical difference in gender between the two groups(P=0.506>0.05).The average age of the observation group was 49.83±14.81 years,while that of the control group was 45.53±14.35 years,with no statistical difference in age between the two groups(P=0.290>0.05).The average course of disease in the control group were 89.07±28.89 months,observation group were 102.13±35.38 months.No significant difference has been found in the course of disease between the two groups(P=0.123>0.05).In terms of effective rate,the number of effective cases in the observation group after 3 weeks treatment was 28(4cases cured,17 cases effective and 7 cases effective),and the effective rate was 93.33%.The effective cases in the control group were 23(1 cases cured,14 cases effective and 8 cases effective),and the effective rate was 76.67%.By nonparametric rank sum test,the effective rate of the observation group was higher than that of the control group with statistical significance,(P 0.014<0.05).After 4 weeks follow-up,the number of recurrence cases in the observation group was 7,and the recurrence efficiency was 25.00%.The number of recurrence cases in the control group was 10,and the compound efficiency was 43.47%.By nonparametric rank sum test,the recurrence rate in the observation group was lower than that in the control group,which was statistically significant,(P=0.390<0.05).Constipation symptoms and efficacy evaluation were no statistical difference between the two groups before treatment(P=0.198>0.05),and the observation group was superior to the control group in constipation symptoms and efficacy evaluation after 3 weeks treatment with statistical significance(P 0.037<0.05).The observation group was also better than the control group in constipation symptoms and efficacy evaluation after stopping use of the medicine 4weeks with statistical significance(P=0.017<0.05).There was no statistical difference in TCM syndrome score between the two groups before treatment,(P=0.414>0.05).After 3 weeks of treatment no statistical difference in TCM syndrome score between the two groups,(P=0.233.>0.05).The observation group was superior to the control group in improving fatigue(P=0.044<0.05),Qi shortness and talking laziness(P=0.018<0.05)with statistical significance.There was no significant difference in the total score of TCM syndromes between the observation group and the control group after stopping use of the medicine 4 weeks.There was no significant difference in quality of life score between the two groups before treatment,with no statistical difference,(P=0.446>0.05).After 3 weeks treatment,quality of life score in the two groups both improved,but no statistical difference was found between the observation group and the control group,(P=0.300>0.05).No statistical difference between the two groups in life quality score of the two groups after stopping use of the medicine 4 weeks,(P=0.193>0.05).There was no significant difference in the number of cases with spontaneous complete defecation more than 3 times per week between the two groups before treatment(P=0.492>0.05).After 3 weeks treatment,the number of cases with spontaneous complete defecation more than 3 times per week in the two groups was counted.It was found that the observation group was superior to the control group in increasing the frequency of defecation,(P=0.020<0.05).Then,counting the number of cases with Spontaneous complete defecation(?3 times per week)in the two groups after stopping use of the medicine 4 weeks.The observation group was also better than the control group in increasing the frequency of defecation,(P=0.006<0.05).There were no obvious abnormalities in blood routine,liver and kidney function before and after treatment in the observation group,and no adverse reactions occurred in the two groups during the medication period.Conclusion:The Chang Zhou Tong Bian decoction of my tutor was superior to the Qi Rong Run Chang Oral Liquid in the treatment of constipation with deficiency of both Qi and Yin,increasing the frequency of Spontaneous defecation and improving the symptoms of constipation.There was no significant difference in total scores of TCM syndromes between the two groups after 3 weeks treatment.The effect of Chang Zhou Tong Bian decoction on fatigue,Qi shortness and talking laziness was better,which showed that Chang Zhou Tong Bian decoction was better than Qi Rong Run Chang Oral Liquid in tonifying the middle qi.The recurrence rate of observation group was lower than that of control group after stopping use of the medicine 4weeks,and Chang Zhou Tong Bian decoction was better than Qi Rong Run Chang Oral Liquid in long-term effect.Both groups had good effect in improving the quality of life.Therefore,Chang Zhou Tong Bian decoction had a very good clinical effect in the treatment of constipation of deficiency of both Qi and Yin,which was safe and suitable for widespread clinical application. |
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