| Objective: By observing the clinical effect of Jianpizishen decoction in treating breast cancer insomnia to objectively evaluate its safety and efficacy.In order to provide ideas and methods for the treatment of dysmenorrheal of chong-ren Syndrome after endocrine therapy of breast cancer.Method: 60 cases were randomly divided into treatment group and Control group(30 cases each).Treatment group was given Jianpizishen decoction,control group was given alprazolam tablets,7 days for a course of treatment,two groups were treated for 2 courses.To observe the change of TCM symptom score,TCM symptom curative effect,insomnia curative effect and PSQI total score before and after treatment.Results: 1.The scores of TCM symptoms in the two groups were improved after treatment(P < 0.01),and the improvement in the treatment group was better than that in the control group(P < 0.01).The effective rate of the treatment group was 86.6%,and that of the control group was 63.3%,the difference was statistically significant(P < 0.05),which showed that the effect of Jianpizishen decoction was better than that of Alprazolam.3.After treated,the effective rate of insomnia symptom improvement was 80% in the treatment group and 90% in the control group,there was no significant difference(P > 0.05),which showed that the effect of Jianpizishen decoction was similar to that of Alprazolam decoction.4.The total score of Pittsburgh Sleep Quality Index(PSQI)of the two groups before and after treatment was compared,and both the treatment group and the control group were improved(P < 0.01),and there was no significant difference between the two groups(P> 0.05).It is suggested that Jianpizishen decoction is as effective as Alprazolam in improving sleep quality.Conclusion: Jianpizishen decoction is a safe and effective method to treat breast cancer patients with insomnia after endocrine therapy,improve sleep quality and improve systemic symptoms. |
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