| Objective:On the basis of reviewing the literature and clinical practice,the efficacy and safety of the rapid analgesic effect of migraine was evaluated by observing the clinical study of the rapid analgesic effect of Sitong Sansai on the acute exacerbation of migraine.Methods:In this study,50 patients with migraine were selected by randomized controlled method,including 28 in the treatment group and 22 in the control group.The treatment group was treated with Sitong powder for nasal obstruction and the control group was treated with ibuprofen sustained-release capsule.Both groups were treated with drugs at the onset of headache.The observation times were once.The number of headache disappearance in 2 hours after treatment was recorded,and the headache relief rate was more than 50%in 2 hours after treatment.The VAS scores of 0.5h,1h,2h,4h and 24h before and after treatment,the scores of accompanying symptoms and the recurrence rate of 48hours were used to evaluate the effect of Sitongsan on rapid analgesia in migraine attack.SPSS21.0 was used for statistical analysis.All statistical tests were performed by bilateral test,with P<0.05 as the statistical significance and P<0.01as the significant statistical significance.Results:1.1.Generally,there was no significant difference in course,age and sex between the two groups(P>0.05).There was no significant difference in VAS score and accompanying symptom score between the two groups before medication(P>0.05),which was comparable.2.Comparison of main therapeutic indexes of headache:After medication,the number of headache disappearance in the treatment group and the control group was 32%and 36%,respectively.The number of headache disappearance in the treatment group was slightly lower than that in the control group,with no statistical significance(P>0.05).3.Comparisons of Secondary Therapeutic Indicators of Headache:(1)21 patients in the treatment group had headache relief of more than 50%within 2 hours after treatment,with an effective rate of 75%;17 patients in the control group had headache relief of more than 50%within 2 hours after treatment,with an effective rate of 77%.Comparing the two groups,the treatment group was slightly lower than the control group,and there was no statistical difference(P>0.05).(2)VAS scores of the two groups were compared,VAS scores of the two groups were improved at 0.5h,1h,2h,4h and 24h after treatment(P<0.05).Compared with the control group,the VAS score of the treatment group was significantly improved after0.5 hours of treatment(P<0.05).(3)Comparisons of the scores of accompanying symptoms between the two groups,the scores of accompanying symptoms in the two groups at 1,2,4 and 24 hours after administration were improved compared with those before treatment(P<0.05).Compared with the control group,the improvement of symptoms score in the treatment group was significantly better than that in the control group at 0.5 h,2h and 4h after treatment(P<0.05).(4)The disappearance of the accompanying symptoms at 2 h after treatment was compared between the two groups.The disappearance of the accompanying symptoms at 2h after treatment was photophobic(82%),dizziness(69%),nausea(67%),vomiting(57%),and tearing.(40%),blurred vision(33%),flash in front of eyes(25%),the disappearance of symptoms associated with the control group 2 hours after the medication was dizziness(55%),nausea(50%),vomiting(29%),Photophobia(22%),tearing(20%),blurred vision(0%)and flash in front of the eyes(0%),and the treatment group improved the photophobia symptoms better than the control group,the difference was statistically significant(P<0.05).(5)Comparing the onset time of the two groups,the treatment group was 14.67+6.48 min,and the control group was 28.47 + 5.43 min.The treatment group was significantly better than the control group,and the statistical difference was significant(P<0.01).(6)Compared with the recurrence rate within 48 hours after medication,7 cases recurred within 48 hours,the recurrence rate was 25%,22 cases in the control group and 8 cases in the control group.The recurrence rate was 36%.There was no significant difference in the recurrence rate between the two groups(P>0.05).Conclusions:1.Sitongsan can effectively alleviate the headache degree of migraine patients during the attack period.The ratio of headache disappearance 2 hours after medication,the headache relieved more than 50%after 2 hours of medication and the improvement of VAS score is not inferior to ibuprofen sustained-release capsules.2.The onset time of Sitong Sansai Nasal is obviously better than that of ibuprofen sustained release capsule,and it can significantly improve the symptoms of photophobia.In the migraine attack period,the method of nasal administration has certain advantages,the rapid analgesic effect is obvious,and the medicine is simple and effective,and it is worthy of being applied in clinical practice. |
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