Preoperative Versus Postoperative Administration Of Paracoxib In Nasal Endoscopic Surgery: Effect On Postoperative Pain Controll

Objective:To investigate the efficacy of preemptive analgesia with parecoxib for acute postoperative pain management after nasal endoscopic surgery.Methods:Selecting sixty patients whose American Society of Anesthesiologists (ASA) status wasâ… -â…¡and who were scheduled for nasal endoscopic surgery were randomly devided in two groups (thirty cases each group). In group A, parecoxib 40 mg was injected 15 min preoperatively. In group B, parecoxib 40 mg was injected at the end of operation. If the pain treatment did not provide satisfactory analgesia, pethidine was given as rescue medication. The analgesic effect was evaluated by VAS score (0-10,0=no pain,10=worst pain) at 2,4,6,12 and 24 h after surgery. The adverse effects were observed. The number of the patients who received rescue medication and the patients'global evaluation of the postoperative analgesia were recorded.Results:Activity VAS in the group A was significantly lower than group B, Resting VAS was not so different between the two groups. In groups, rescue medication is only given to 3 patients in group B. There was no significantly difference in adverse effects between the two groups. The level of patient's satisfaction was higher in group A than in group B.Conclusions:Parecoxib 40 mg can relieve postoperative pain and it had been proven safety in patients undergoing nasal endoscopic surgery, especially given preoperatively because it has greater analgesic effects.