Clinical Observation Of The Instant Analgesic Effect Of The Migraine Without Aura Patients In Stage Of Attack By Ear Vein's Bloodletting And Research Its Action Mechanism

Objective:To observe and evaluate the clinical instant analgesic effect of the migraine without aura patients in stage of attack by bloodletting via ear vein ,and through the animal experiment provisionally discusses its action mechanism.Method: By the way of random and control trial,40 migraine without aura patients in stage of intervals were randomly assigned into treatment group and control group,the post aur venous blooding group with 20 patients and control group in which 20 patients took orally Ergotamine caffeine.Observe the change of McGill gauge integral before and after the patients'treatment.By the same way of random and control trial,30 New Zealand rabbits were randomly averaged into three groups,common group,model group and blooding group.Bled the two ears of rabbits in blooding group,observed the change of pain threshold,and tested the content of SP,CGRP in rabbits'blood plasma and brainstem.Result:â‘ The post aur venous blooding have the patent clinical analgesia effect of the migraine without aura patients in stage of attack (P<0.01),and have no visible differences with control group(P>0.05).â‘¡The post aur venous blooding have the patent clinical analgesia effect to the rabbits model with migraine (P<0.01),and cut down the content of SP,CGRP in blood plasma and brainstem visibly(P<0.05).