| Objective:By means of the First Affiliated Hospital of Hunan Medical University’s collection of 216 cases of gouty arthritis patients were analyzed,and the preliminary discussion on gouty arthritis of TCM syndrome classification and imbalance of pro-inflammatory/anti-inflammatory factor correlation and different TCM syndrome types of distribution of gouty arthritis.Methods: Selected 216 patients with gouty arthritis to dialectical classification(80 cases of damp and hot accumulate knot type,hot and damp stasis type56 cases,phlegm and blood stasis blocking type 57 cases,23 cases of liver and kidney deficiency type),and normal control group 40 cases,detection of two groups of serum proinflammatory factor(IL-1β、IL-6、TNF-α)and anti-inflammatory factor(IL-4、IL-10、IL-13).Certificate based on the type of the disease,clinical manifestations and related laboratory,imaging examination(routine blood,blood sedimentation,c-reactive protein,renal function and renal colour to exceed),objective analysis the syndromes gouty arthritis and inflammation factors interrelated imbalances.Results: 1.Damp and hot accumulate knot type: a total of 80 cases,the highest proportion of patients with gouty arthritis,at 37.04%,age 43 years of age or older,in more of interleukin increased in 19 patients,72 cases of blood uric acid,23 patients with pre-existing renal uric acid calculi,its inflammation index readings are the highest in the four kinds of TCM syndrome types,CRP was 63.96 ± 23.07,the ESR was 52.63±15.82.The positive rate of IL-1β was 92.50%,and the detection value was 73.75±14.05.IL-6 positive rate was 88.75%,the values of 53.39±16.56.TNF-α positive rate was 85.00%,the values of 82.95 ± 24.14.Anti-inflammatory factor IL-4 positive rate was 85.00%,the detection value of 11.00±4.70.The positive rate of IL-10 was 91.25%,the detection value of 28.13 ± 5.55.The positive rate of IL-13 was 12.52% and the detection value was 20.10±2.30.2.Hot and damp stasis type: a total of 56 cases,accounting for 25.93% of the total number of cases,age in 45 years of age or older,more higher of white blood cells in 5 patients,31 cases of blood uric acid,15 patients with pre-existing renal uric acid calculi,the CRP values was 39.68 ± 13.48,the ESR was 48.63 ± 12.68.The positive rate of IL-1β was 94.64%,and the detection value was 55.26 ± 12.96.IL-6 positive rate was 87.50%,the values of 39.22±12.88.TNF-α positive rate was82.14%,the values of 60.50±16.61.Anti-inflammatory factor IL-4 positive rate was78.95%,the detection value of 12.16±3.81.The positive rate of IL-10 was 89.29%,the detection value of 20.00 ± 3.21.The positive rate of IL-13 was 7.14% and the detection value was 15.80±6.22.3.Phlegm and blood stasis blocking type: a total of 57 cases,accounting for26.39% of the total number of cases,age 52 years of age or older,in more relatively long course of the disease,there were 3 cases of patients with elevated white blood cell,1 case of patients with leukopenia,40 cases of blood uric acid,18 cases of renal uric acid calculi,the CRP values was 28.55 ± 10.34,the ESR was32.77 ± 9.83.The positive rate of IL-1β was 92.98%,and the detection value was 49.47 ± 12.51.IL-6 positive rate was 87.72%,the values of 30.36±14.57.TNF-α positive rate was82.46%,the values of 53.18±21.37.Anti-inflammatory factor IL-4 positive rate was78.95%,the detection value of 17.13±3.49.The positive rate of IL-10 was 82.46%,the detection value of 17.13 ± 3.49.The positive rate of IL-13 was 5.26% and the detection value was 18.08±1.79.4.Liver and kidney deficiency type: a total of 23 cases,accounting for 10.65% of the total number of cases,age 60 years of age or older,in more relatively long course of the disease,there were 2 cases of patients with elevated white blood cell,2 case of patients with leukopenia,11 cases of blood uric acid,8 cases of renal uric acid calculi,the CRP values was 11.45 ± 5.62,the ESR was 18.39 ± 6.81.The positive rate of IL-1β was 91.30%,and the detection value was 34.87±15.27.IL-6 positive rate was86.96%,the values of 18.16±11.11.TNF-α positive rate was 82.61%,the values of50.50 ± 8.88.Anti-inflammatory factor IL-4 positive rate was 13.04%,the detection value of 5.00 ± 1.17.The positive rate of IL-10 was 30.43%,the detection value of10.24±3.24.The positive rate of IL-13 was 0%.Conclusion: Gouty arthritis of TCM syndrome and the expression of proinflammatory factor and anti-inflammatory factors exist a certain correlation,presumed to TCM “hot” factors related to the rise of proinflammatory factor,”the imaginary” factors associated with the reduce of anti-inflammatory factor.Traditional Chinese medicine can inhibit proinflammatory cytokines(dispel pathogens)andstrengthen the expression of anti-inflammatory factors(even the upright)to study the treatment of gout. |
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