| Menopause is the period in which woman transits from sexual maturity to old age and physical change is the most obvious.It's the most important transition in woman's life.Climacteric syndrome includes a series of symptoms which result from estrogen' s decrease,such as menses change,face redness,palpitate,loss sleep,etc.Those affect women' s health,mind and life and are related to their sound in body and mind and life's quality after menopause,which maybe lead to increase dual burden of family and society.So the prevention and timely treatment of menopause can let women pass this period favorably and have momentous current and social significance.It' s treated by HRT against obvious low estrogen' s decrease in menopause,but long-use of HRT has patent danger,such as increased risk of endometrium and galactophore cancer,gaining in weight,irregular bleeding in vagina and so on,which decrease women's acclimatization of HRT in menopause.Climacteric syndrome is included in "menopausal syndrome" in China Medicine,tradition Chinese medicine and pharmacy have advantages against WM,because of averting a great deal of untoward reactions from therapy of WM.So the curative effect observation on treating climacteric syndrome bytradition Chinese medicine and pharmacy answers for clinical need and will have good social and financial benefits.ObjectiveTo study modified Diankuangmengxing and Xiaoyaosan dectotion mechanism and advantages in the treatment of women' climacteric syndrome through the observation of symptoms,experimental index and efficacy and comparison with control group with WM.MethodObjects meet both the differentiation standard of yin asthenia generating intrinsic heat and diagnostic criteria of climacteric syndrome.Out-patients were clevided into control group with HRT and treatment group with modified Diankuangmengxing and Xiaoyaosan dectotion.Examined and compared the clinical efficacy,Kupperman Menopause Index score,estradio,follicle-stimulating hormone and luteotropic hormone.Then evaluate the efficacy and safety of modified Diankuangmengxing and Xiaoyaosan dectotion.Grouped data was analyzed by ?2 test and ranked data was analyzed by rank sum test.Two sample means and were compared by t test or rank sum test.Self circa were compared by matched-pairs t test or rank sum test.Result72 cases is included and devided into 2 group averagely.The more explicit rate of treatment group is 75.0%and control group is 69.4%.The difference were not significant(P>0.05),which meaned that the modified Diankuangmengxing and Xiaoyaosan Decoction had same effect with control group in climacteric syndromes.Kupperman Menopause Index scores of two groups had decreased after treatment,but treatment group's was lower than control group's.So the former had advantages over the latter,two groups of E2,FSH and LH increased in both before and after treatment,but treatment group' s was less obvious than control group's.The treatment group had more effective than the control group in endocrine.All paitents had no side effects and abnormal changes in the index of blood,urina,excrement and liver and kidney function.Clinical research showed that both of drugs had high safty.ConclusionIn treating woman's climacteric syndrome,the Modified Diankuangmengxing and Xiaoyaosan Decoction can meliorate symptoms,signs and hormone index without apparent side effects.It can incease patients' quality of life safely,supassing the contol group.This study showed the Modified Diankuangmengxing and Xiaoyaosan Decoction has its advantages and features in treating woman's climacteric syndrome and will be a new method. |
PDF Full Text Request