Study On Medication Rules Of Professor Cai Gan In Herbal Paste Based On Data Mining

Objective: To study the medication rules of Professor Cai Gan in herbal paste by data mining,so as to provide clinical reference for TCM clinical application of TCM paste prescription and have certain clinical guiding significance.Methods: This study collected 1989 clinical cases of paste prescription from professor CAI gan in 2012 to 2018,and used excel to input data to establish a database.Descriptive analysis was conducted on age and gender,and frequency analysis was conducted on visits,symptoms,tongue veins,syndrome types,drugs and diseases.Frequency analysis was conducted on the four qi,five flavors,meridians and efficacy of37 traditional Chinese medicines with occurrence frequency of more than 600 times and percentage of more than 30%.Factor analysis was conducted on 50 traditional Chinese medicines with a percentage of more than 20%,and correlation analysis was conducted on the relationships among "symptom-syndrome","disease-drug" and "drug-drug".Logistic regression analysis was conducted to analyze the relationship between "syndrome and drug".Results: 1.There were 1,989 people in total,including 1,145 women and 844 men,and the ratio of male to female was 1:1.36.The 51-60 age group accounted for the largest number,accounting for 25.19% of the total population.Meanwhile,370 patients visited the hospital more than twice,accounting for 18.6% of the total number.2.In 1989 cases of paste prescription,46 diseases were found,including functional constipation,chronic gastritis,hypertension,hyperlipidemia,atrophic gastritis,fatty liver,diabetes,gallstones,hyperuricemia,duodenal ulcer,etc.There were 40 syndromes in total,among which the syndromes with frequency more than 400 times included liver depression and spleen deficiency,damp-heat accumulation of spleen,deficiency of heart and spleen,and deficiency of kidney essence.There were 94 kinds of symptoms in total,and the symptoms with frequency more than 300 times included fatigue,lumbar acid,restless sleep,epigastric distension and suffocation,epigastric pain,belching,acid swallowing,fecal secretion and dizziness.A total of 258 Chinese herbal medicines were found,among which the ones more than 1000 times were poria cocos,radix glycyrrhizae,orange peel,pinellia ternata,radix pseudostellariae,rhizoma coptidis,rhizoma coptidis,fructus amomum,cardamom,atractylodes macrocephala,forsythia forsythiae,turmeric,dendrobium,fritillaria thunbergii,Chinese yam,radix scutellariae,salvia miltiorrhiza,walensis and bupleurum.In addition,the efficacy,four qi and five flavors and frequency of meridians of 37 traditional Chinese medicines with occurrence frequency more than600 times and percentage greater than 30% were analyzed,and it was concluded that the ratio of tonic drugs to cathartic drugs was 1:2.5,the ratio of cold and temperature was close to 1:1,the ratio of sweet drugs to bitter drugs was 1:1.17,and the drugs attributed to liver and spleen meridians were the most.3.Through factor analysis of 50 traditional Chinese medicines with a percentage greater than 20%,14 commonly used drug combinations were obtained.4.The relationship of "symptom-syndrome","disease-medicine" and "medicine-medicine" was obtained through correlation analysis;The relationship between "syndrome and drug" was obtained through logistic regression analysis.Conclusions: 1.The study found that the number of patients aged 51-60 who took the cream prescription was the highest,and the kidney qi deficiency and deficiency of vital qi in this age group were easy to cause disease.Therefore,the most suitable for paste recuperation,improve the human body.2.Through data mining,the characteristics of the commonly used traditional Chinese medicine,the commonly used drug combinations and the relationship among "symptom-syndrome","syndrome-medicine","disease-medicine" and "medicine-medicine" are obtained.3.Summarize the characteristics of professor CAI gan's medication: gan bu kuxie,tong bu shi;Cold and warm,mild medication;Lifting and balancing,protecting the spleen and stomach;Address both symptoms and root causes.