Professor Liu Wenfeng's Clinical Experience In The Treatment Of Diabetic Ketosis And Ketoacidosis

PurposeDig into and analyze the rules of doctors' treatment of diabetic ketoacidosis and ketoacidosis in recent years,and summarize Professor Liu Wenfeng's academic thoughts,clinical experience,and self-made analysis of diabetic ketosis and ketoacidosis.Compare the similarities and differences between Professor Liu Wenfeng and other doctors in the treatment of diabetic ketosis and ketoacidosis,and extract the uniqueness of Professor Liu Wenfeng in the treatment of diabetic ketosis and ketoacidosisMethodsThrough literature research,combing the research progress of traditional Chinese and western medicine on diabetic ketosis and ketoacidosis in recent years,and clarifying the background for the treatment of diabetic ketosis and ketosis in recent yearsBased on the traditional Chinese medicine supporting platform 2.5,establish a database of 225 prescriptions for diabetic ketoacidosis and ketoacidosis in recent years,and use data mining for prescription Chinese medicine drugs,medicines,medicinal properties,medicinal flavors,and meridians,etc.Frequency analysis,frequency analysis,and correlation analysis are used to summarize the prescriptions of traditional Chinese medicine prescriptions for diabetic ketosis and ketoacidosis in recent yearsSummarize the academic thoughts of Professor Liu Wenfeng in the treatment of diabetic ketosis and ketoacidosis with traditional Chinese medicine,and analyze their own prescriptions,and compare with the medication rules of other doctors.Uniqueness of poisoningResultsBased on the traditional Chinese medicine supporting platform,225 prescriptions for diabetic ketosis and ketoacidosis in recent years have involved data mining of 174 traditional Chinese medicines.It was found that Coptis chinensis was used the most frequently and accounted for the largest proportion;there were 14 flavors of medicines with a frequency of>60 times,accounting for 50.36%of the total frequency.The overall medication is mainly heat-clearing drugs,followed by qi-enhancing drugs and nourishing yin medicine;the overall medication is mainly cold-cooling drugs,which accounts for the largest proportion;Correlation analysis was performed on 174 traditional Chinese medicines in 225 prescriptions,and 17 drug pairs with the highest frequency of simultaneous occurrence were obtained.Respectively:Xuan participates in Ophiopogon,Coptis chinensis and Habitat,Ophiopedidium and Astragalus,Coptis genus and Trichosanthin,Astragalus and Pueraria,Ophiopogon and Pueraria,Ophiopogon and Habitat,Xuan participates in Coptis,Xuan participates in Astragalus,Xuan participates in Pueraria,Cotinus coptis,Ophiopogon and Coptis chinensis,Yam and Coptis,Yam and Astragalus,Dan participate in Pueraria,Schisandra and Ophiopogon,Ophiopogon,Astragalus and PuerariaBased on the improved mutual information method,there are 16 drug pairs with correlation coefficients greater than 0.4,which are:Schisandra chinensis and Trichosanthin,Diospermum and Salvia,Coptis chinensis and Trichosanthin,Puerariae and Pseudostellariae,Puerariae and Perilla leaves,Laizizi and Poria,Schisandra and Rhubarb,Xuan participates in Salvia miltiorrhiza,Rhubarb and Peony skin,Schisandra and Gardenia,Honeysuckle and sage,Honeysuckle and Eucommia,Honeysuckle and Schisandra,Honeysuckle and Zihuadi,Astragalus and Scrophularia,Gypsum PoriaUsing the association rule mining method,the support degree is greater than or equal to 0.5,and 17 drug core combinations are obtained:bamboo leaves,bile star,antelope horns;forsythia,honeysuckle,lotus seeds;codonopsis,jade bamboo,dendrobium;Laizizi,rhubarb,Daqingye;Mallow Seed,Zelan,Dilong,Bupleurum,Curcuma,Wang Buling;Gypsum,Anemarrhena,Japonica;Anemarrhena,Rhododendron,Trichosanthin;Scutellaria baicalensis,Coptis chinensis,Gardeniae;Laizizi,Red Loquat,peony skin,big green leaves;Yuzhu,Panax notoginseng,Lycium barbarum;almonds,barley kernels,Tongcao,Baikouren;oysters,red ginseng,Zhigancao;almonds,Tongcao,talc,Magnolia;jujube kernels,Polygala,Tianzhi Winter,Bo Ziren;Bamboo Ru,Pinellia ternata,Zhishi,Chenpi;Cardamom,Laizizi,Aconite,Dried Ginger.8 new prescriptions were derived,namely:Scutellaria baicalensis,Coptis chinensis,Perilla leaf,Gardenia;Forsythia suspensa,Hedyotis diffusa,Honeysuckle,Lotus seed;Bamboo leaves,almond,Tongcao,bile star,antelope horn;Cimicifuga,Glauber's salt,Rhubarb,Laizizi,Daqingye;Bupleurum,Psyllium,Mallow,Zelan,Dilong,Curcuma,Wang Buling;Laizizi,Chenpi,Daqingye,Zhuru,Pinellia,? Fruit;Coix seed,Ghost arrow feather,Litchi nucleus,Almond,Tongcao,Baikouren;Angelica,Chuanxiong,Chiba,Laizizi,Peony skin,DaqingyeProfessor Liu Wenfeng concluded that the basic etiology and pathogenesis of diabetic ketosis and ketoacidosis are as follows:Qi-yin deficiency is the basis,and damp-heat,turbidity,and poisoning are the targets.Diabetic ketosis and ketoacidosis are mainly based on internal organs and deficiencies,and external and internal evils are the standard.They are not one organ,one organ,and one single disease.They are multiple organs,multiple organs,and deficiencies.Causes the body's qi and yin deficiency,fluid loss,and abnormal operation,which leads to the metaplasia of pathological products such as phlegm drinking,stasis,and damp heat,which are intertwined and affect each other.It becomes poisonous,the internal organs become more debilitated,and the qi,blood,and fluid are more and more blocked.So hot and turbid poisoning rages eventually leading to a serious illness and the diseaseFor the treatment of diabetic ketosis and ketoacidosis,Liu Wenfeng took a bold medication,using the "hot person cold" as a guideline,using large amounts of heat-clearing drugs,which accounted for half of the heat-reducing drugs.The effect of evil is to drive away evil with great efforts.The "law of lifting pots" has been developed and applied,so that evil can emerge from the second place.Many evils accumulate in the body and block the air machine,so the whole party grasps the removal of the wet evil and the operation of the air machine from the lungs,spleen,stomach and liver.Professor Liu pays attention to the nature,taste,and meridian of medicines.The medicines of bitterness and sweetness are used together,so that medicines can be used in the clinics to maximize the effect of medicines.The medicines of Xinsan are used to take the medicines of Xinsan and Xing,and to unblock the body Qi machine?He reuses the medicine into the lung meridian,while taking into account the medicine into the liver,spleen and stomach.The prescription nourishes yin and regenerates fluids at the same time to prevent evils,so as to prevent the evils from attacking too much,and make the medicines work togetherProfessor Liu Wenfeng has some similarities and breakthroughs in the treatment of diabetic ketosis and ketoacidosis with other doctors.In terms of medication,Professor Liu Wenfeng applied antipyretics in large doses in Qinlian Xiaoke Drink,which coincided with the results of the previous data mining analysis of medications for diabetic ketosis and ketoacidosis.Of the 13 traditional Chinese medicines prepared by Professor Liu,8 of them are cold and cold,accounting for more than half,and 5 of them are sweet,and the number of medicines is the most.This is consistent with the previous rules for the treatment of diabetic ketosis and ketoacidosis.In addition,the prescription of Qinlianxiaoketone contains data mining new formula 1(Scutellaria baicalensis,Coptis chinensis,Perilla leaf,Gardenia jasminoides).Professor Liu Wenfeng pays more attention to the taste and return to the classics in the treatment principles and prescription groups to maximize the effect of the drugs.Conclusion:Based on the data mining of 225 prescriptions based on the traditional Chinese medicine inheritance platform,the modern doctors' treatment of diabetic ketosis and ketoacidosis is mainly heat clearing and tonic medicine,and the treatment direction is clearing heat,nourishing qi and nourishing yin.They mainly use cold medicine,sweet and bitter medicine.Their treatment of diabetic ketosis and ketoacidosis has a lot in common with the treatment of basic disease diabetes.The new formula based on entropy cluster analysis provides a new direction for our treatment of diabetic ketosis and ketoacidosis.Professor Liu Wenfeng has been engaged in the diagnosis and treatment of traditional Chinese medicine for more than 50 years,especially in the treatment of diabetes and diabetic complications.This study summarized the academic thoughts and clinical experience of Professor Liu Wenfeng from the etiology,pathogenesis,treatment principles,and prescription medication of diabetic ketosis and ketoacidosis.This study embodies its "Zhongzhong Shenxi"thinking,which has certain reference significance for clinical doctors in the treatment of diabetic ketosis and ketoacidosis.