| Objective:To observe the clinical efficacy of Bushen Kangshuai Tablet on patients with morning hypertension of deficiency syndrome of both yin and yang.Methods:Patients with morning hypertension(deficiency syndrome of both yin and yang)who were diagnosed and treated in the First Affiliated Hospital of Tianjin University of TCM from January 2018 to June 2019 were selected as the research subjects,and 60 patients who met the inclusion criteria were randomly divided into control group and experimental group,30 cases in every group.The control group took oral amlodipine besylate tablets(5mg once,once a day),valsartan tablets(40mg once,once a day);On the basis of the treatment in the control group,the experimental group was treated with Bushen Kangshuai tablet orally(6tablets at a time,3 times a day)for 4 weeks.Observed the morning blood pressure control compliance rate and efficacy,morning blood pressure drop level and magnitude,as well as average blood pressure(24-hour average systolic blood pressure(24h SBP),24-hour average diastolic blood pressure(24h DBP),daytime average systolic blood pressure(d SBP),daytime average diastolic blood pressure(d DBP),night average systolic blood pressure(n SBP),night average diastolic blood pressure(n DBP),blood pressure circadian rhythm,TCM syndrome score,Du's hypertension quality of life score and other index changes.Results:(1)Morning blood pressure control compliance rate and efficacy:after treatment,the experimental group morning blood pressure control compliance rate(97%)was better than the control group(73%),the difference was statistically significant(P<0.05).The total effective rate of the experimental group after treatment(93.33%)was higher than that of the control group(73.33%),and the difference was statistically significant(P<0.05).(2)Morning blood pressure decrease level and amplitude:compared with before treatment,the SBP and DBP of the two groups were significantly decreased after treatment in the morning,and the difference was statistically significant(P<0.01);the experimental group had better morning SBP and DBP decrease levels and amplitude after treatment compared with the control group,the difference was statistically significant(P<0.05),and the amplitude of morning SBP decrease in the experimental group was significantly greater than that in the control group,and the difference was statistically significant(P<0.01).(3)Average bloodpressure:compared with before treatment,the average SBP and DBP of the two groups after each treatment period all decreased,the difference were statistically significant(P<0.05).After treatment,the average SBP and DBP decrease levels of the experimental group were better than those of the control group,and the differences were statistically significant(P<0.05).(4)Circadian rhythm of blood pressure:two groups had no significant difference(P>0.05).(5)TCM syndromes:compared with before treatment,the total scores of syndromes and main symptoms of the two groups after treatment were decreased,the difference was statistically significant(P<0.05);the total score decrease of syndromes of the experimental group after treatment was significantly better than the control group,the difference was statistically significant(P<0.01);the experimental group was superior to the control group in improving the main symptoms(vertigo,headache,backache,knee softness,cold chills),the difference was statistically significant(P<0.05);The total effective rate of syndrome improvement in the experimental group(90%)was higher than that in the control group(66.66%),the difference was statistically significant(P<0.05).(6)Quality of life:compared with before treatment,the total score,physiological symptoms,physical symptoms,anger or vitality,sleep status,anxiety,depression and other items of the experimental group after treatment increased significantly,and the difference was statistically significant(P<0.01),but there were no significant difference in the scores of sexual dysfunction,obsessive-compulsive symptoms,interpersonal sensitivity,work status,hostility,etc.(P>0.05);Compared with before treatment,the control group's total score,physiological symptoms,physical symptoms,sleep status and other items increased(P<0.05),while anger or vitality,anxiety,depression,sexual dysfunction,obsessive-compulsive symptoms,interpersonal sensitivity,working status,hostility and other items have no obvious difference(P>0.05).After treatment,the scores of physical symptoms,physical symptoms,anxiety and depression of the experimental group were higher than those of the control group(P<0.05),but there was no difference in anger or vitality,sleep status,sexual dysfunction,obsessive-compulsive symptoms,interpersonal sensitivity,working status and hostility(P>0.05).The single symptoms of chest tightness,easy to feel nervous and fear,and tinnitus score of the experimental group were better than those of the control group(all P<0.05),and the cold limbs symptom score of the experimental group was significantly better than the control group(P<0.01).Conclusion: Bushen Kangshuai Tablets combined with conventional antihypertensive drugs can improve the compliance rate and antihypertensive effect of patients with the morning hypertension(deficiency syndrome of both yin and yang),increase morning blood pressure drop level and blood pressure drop degree,and lower the average blood pressure(24h SBP,24 h DBP,d SBP,d DBP,n SBP,n DBP),and can improve TCM syndromes and quality of life of patients. |
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