Clinical Observation On The Treatment Of Hashimoto's Thyroiditis With Tonifying Kidney And Invigorating Spleen Decoction Combined With Sodium Levothyroxine

Research purposes:To observe the changes in thyroid function and other aspects of Hashimoto's thyroiditis patients treated with Wenbupi Shenfang combined with levothyroxine sodium tablets,and to analyze the effect of treatment and explore its mechanism.The evaluation of its treatment safety provides effective prescriptions for the treatment of Hashimoto's thyroiditis patients with traditional Chinese medicine.Research method:Select 60 patients who meet the diagnostic criteria for Hashimoto's thyroiditis with spleen-kidney deficiency syndrome.The included patients were given diet and lifestyle guidance,increased the proportion of low-iodine food,and exercised scientifically.The control group was treated with Youjiale,and the treatment group was supplemented with Wenbu Pishen formula on the basis of the control group,with 30 cases in each group.Observe changes in indicators such as disease efficacy and TCM clinical syndromes,and analyze these data statistically.Research result:?Before treatment,the two groups of patients had no significant differences in age,course of disease,laboratory indicators,and TCM symptom scores(P>0.05),which were comparable.? Analysis of disease efficacy,the total effective rate in the treatment group was 83.33%,and the control group was 70.00%,with significant differences between the groups(P<0.05).The treatment group had better results.? The efficacy of the syndrome shows that,in terms of the total effective rate,the treatment group finally obtained a result of 86.67%after statistical calculation,and the control group was 66.67%.The total effective rate between the treatment group and the control group was significantly different(P<0.05).This means that the treatment group has better syndrome efficacy.? TCM symptoms improved:After treatment,compared with before treatment,the treatment group significantly improved the symptoms of TCM(P<0.05);while in the control group,the patients had cervical bloating,facial swollen limbs,anorexia,hyposexuality and defecation.The improvement of weakness symptoms was significant(P<0.05),and other indicators were not significantly improved(P>0.05).Compared with the control group,the patients in the treatment group had anterior cervical cysts,facial swollen limbs,dysphagia,and decreased libido after treatment.And defecation weakness were significantly improved(P<0.05);this means that all symptoms in the treatment group were improved,while the control group could only improve the symptoms of anterior cervical cysts,facial swollen limbs,anorexia,hyposexuality,and defecation weakness,and the treatment The group was far superior to the control group in improving the symptoms of the five groups,especially the symptoms of anterior cervical bloating,facial swollen limbs,and dysphagia.? TCM Syndrome Scores:The total scores of the syndromes of both groups of patients have improved,and the difference is significant,(P<0.01).Compared between groups,the difference is also more significant(P<0.01),and the treatment group has a more significant improvement.? Comparison of the degree and texture of goiter:The degree and texture of goiter after treatment in the two groups were significantly reduced compared with before treatment.After treatment,the treatment group improved more significantly(P<0.05).?)Comparison of thyroid hormone levels and autoantibody levels:Compared with the two groups before and after treatment,the levels of TSH,TGAb,and TPOAb decreased significantly,and the levels of FT3 and FT4 significantly increased,all having significant differences(P<0.01),which was statistically significant.Comparing between the groups,the levels of FT3 and FT4 in the treatment group were significantly higher than those in the control group(P<0.01),the difference was statistically significant,and the levels of the treatment group had a greater decrease(P<0.01).?Thyroid color ultrasound prompt:Both groups have relatively reduced thyroid volume and isthmus thickness(P<0.01),which improves blood flow signals(P<0.05).Compared between groups,the improvement of the treatment group was better(P<0.05).?Safety indicators:No gastrointestinal reactions,such as skin allergy,nausea and vomiting,etc.occurred before and after treatment,and no abnormalities were observed in routine hematuria and feces,liver and kidney functions,etc.Analysis conclusion:This study shows that using Wenbu Pishen formula to treat Hashimoto's thyroiditis with spleen-kidney yang deficiency syndrome has a significant effect,not only can significantly improve patients' thyroid function and thyroid antibody titer levels,thyroid volume and isthmus thickness further decrease after treatment,clinical symptoms and signs It has been effectively improved and has high safety,which deserves further promotion in the clinic.