Evaluation Of The Clinical Efficacy Of Vitamin D-Assisted Therapy For Bronchial Asthma In Adults And Its Effect On The Expression Of Vitamin D Receptor

Background:Bronchial asthma（BA）is one of the most common chronic diseases in the world.More than 10% of the earth’s population is suffering from it,and its prevalence is still rising.Exploring new treatment strategies（such as adjuvant therapy）is the key to better control asthma.In the past decade,the role of vitamin D in the pathogenesis of BA has been the focus of research.The results of these studies confirm the link between vitamin D deficiency and overall deterioration of lung function and symptoms in asthmatic patients.By further exploring the role and mechanism of vitamin D and its receptor in the occurrence and development of asthma,we can help people better understand BA,so as to provide a new way for the prevention and treatment of asthma.Objective:To observe the difference in the treatment effect of vitamin D-assisted therapy on the basis of conventional therapy in improving adult BA,and further explore the changes of vitamin D receptor（VDR）and inflammatory factor level in patients,so as to provide clinical experimental data support for the clinical application of vitamin D-assisted therapy of bronchial asthma.Methods:108 adult BA patients received by our hospital were randomly divided into routine treatment group（group A）,routine dose of vitamin D treatment group（group B）and loading dose of vitamin D treatment group（Group C）.The patients in group B and group C were treated with 400 u / D and 800 u / D vitamin D supplements respectively.The changes of ACT score,serum 25（OH）D3,VDR,Ig E,IL-4 and IL-17 A were measured before and 30,60 and 90 days after the intervention.Results:1.The serum 25（OH）D3 and VDR of BA patients were significantly lower than those of healthy people（P < 0.05）,and the serum levels of Ig E,IL-4 and IL-17 A were significantly higher than those of healthy people（P < 0.05）.Linear regression analysis showed that there was a significant correlation between serum VDR and serum 25（OH）D₃,Ig E,IL-4 and IL-17A（P < 0.05）.2.ACT score showed that after 90 days of treatment,the total control rate of group B was 83.33%,and that of group C was 86.11%,（χ²=0.107 P=0.99,P>0.05）;There was no significant difference between group B and group C.he total control rate of group A was:75%,group B was:83%,（χ²=0.758 P=0.995,P>0.05）There was no significant difference between the two groups 。Groups A and C χ²=1.31P=0.975,P >0.05),There was no significant difference between group A and group C.3.The serum levels of 25（OH）D3 and VDR in group B and group C were significantly increased with the prolongation of treatment time（P < 0.05）,and higher than that in group A,showing a significant time and vitamin D dose-dependent;linear regression analysis showed that 25（OH）D3 and VDR were significantly positively correlated（r = 0.78,P < 0.001）.4.The serum levels of Ig E,IL-4 and IL-17 A in group B and C decreased significantly with the prolongation of treatment time（P < 0.05）,showing a significant time and vitamin D dose-dependent;linear regression analysis showed that Ig E,IL-4and IL-17 A were positively correlated with VDR（P < 0.05）.Conclusion:1Vitamin D can not significantly improve the lung function and asthma control rate of BA patients,which is not better than conventional therapy alone.2 Vitamin D can significantly increase the expression level of VDR and inhibit the expression of related inflammatory factors in asthmatic patients.Can be used as key link in the control of asthmatic inflammation.