Clinical Observation On Treatment Of Damp-heat Vulvovaginal Candidiasis With Shenju Lotion Combined With Clotrimazole Suppository

Objective:By observing the clinical efficacy of Shenju lotion combined with clotrimazole suppository in the treatment of damp-heat vulvovaginal candidiasis,comparing the changes of relevant objective indexes between the treatment group and the control group before and after treatment,and discussing its possible mechanism,To provide new treatment ideas and theoretical basis for the treatment of this disease by traditional Chinese medicine.Methods:60 cases of vaginal candidiasis who met the inclusion criteria were randomly divided into a treatment group and a control group of 30 cases.The treatment group was given Shenju lotion fumigation topical combined with clotrimazole suppository Nayin treatment,the control group was given clotrimazole suppository Nayin treatment for 7 consecutive days,Observe the VVC clinical score,TCM symptom score,vaginal cleanliness classification,quantification of Lactobacillus,and mycology conversion after treatment,the efficacy of TCM syndrome,clinical efficacy,and the month after drug withdrawal.The recurrence rate was statistically processed using SPSS 25.0 software after all data were recorded and collated in detail.Results:1.Baseline data comparison:A total of 60 patients were included in this study.Two patients in the treatment group fell off and one in the control group.57 patients completed clinical observation.The actual completion rates of the two groups were 93.3% and 96.7%respectively.There was no statistically significant difference in age and course of disease between the two groups(P>0.05),which was comparable.There was no significant difference in VVC clinical score,TCM syndrome score,vaginal cleanliness grade,and quantitative comparison of Lactobacillus before treatment(P>0.05).2.Comparison of VVC clinical scores:The difference in clinical scores of VVC between the two groups after treatment was statistically significant(P<0.05),while the difference in clinical scores of VVC before and after treatment between the two groups was not statistically significant(P>0.05).3.Comparison of TCM Syndrome Points:The difference in TCM syndrome scores between the two groups after treatment was statistically significant(P<0.05),and the decreasein TCM syndrome scores of the treatment group after treatment was greater than that of the control group,suggesting that the treatment group had a better effect in improving TCM syndromes.4.Comparison of vaginal cleanliness grading:After treatment,there was a statistically significant difference between the two groups of patients whose vaginal cleanliness was changed to ? and ? degrees(P<0.05),and those in the treatment group who changed to? and ? degrees before and after treatment(89.3%)were higher than the control group(65.5%).5.Quantitative comparison of Lactobacillus:There was a statistically significant difference between the two groups of patients before and after treatment.And the patients in the treatment group changed to a small amount and a large number after treatment(85.7%)than the control group(62.1%).6.Comparison of mycology turned negative:the two groups of patients were positive for mycology before treatment,and there was no significant difference between the two groups after treatment(P>0.05).7.Comparison of efficacy of TCM syndromes:After treatment,the efficacy of TCM syndromes in the two groups was compared.The effective rate of the treatment group was92.9%,and the effective rate of the control group was 82.8%,with a statistically significant difference(P<0.05).8.Comparison of clinical efficacy:After treatment,the clinical efficacy of the two groups of patients was compared.The total effective rate of the treatment group was 96.4%,and the total effective rate of the control group was 89.7%.The clinical efficacy of the two groups of patients was statistically different(P<0.05).9.Comparison of 1-month relapse after drug withdrawal:The difference between the two groups of patients with 1-month relapse was statistically significant(P<0.05),and the1-month relapse rate in the treatment group(11.1%)was significantly lower than the control group(34.6%).Conclusions:1.The application of Shenju lotion combined with clotrimazole suppository for the treatment of damp-heat vulvovaginal candidiasis can effectively reduce the patients' VVC score and TCM syndrome score,and the clinical effect is significant.2.The combination of Shenju lotion and clotrimazole suppository can improve the cleanliness of the vagina and the amount of lactic acid bacteria in patients with vaginalvaginal candidiasis,which is beneficial to the balance of vaginal microecology.3.Shenju lotion combined with clotrimazole suppository is better than single clotrimazole suppository in preventing the recurrence of vulvovaginal candidiasis.4.The mechanism of action of Shenju lotion may be related to inhibiting the growth of pathogenic bacteria and reducing inflammation.