Study On The Correlation Between Insulin?C-peptide And Impairment Of Cerebral Small Vessel Disease

Background:As the aging process of the population accelerates,the incidence of cerebrovascular disease-related cognitive function is increasing year by year,whereas Cognitive impairment associated with cerebral small vascular disease(csvd),which is an important subtype of vascular cognitive impairment.Early diagnosis of csvd-related cognitive impairment is relatively difficult,and patients are difficult found to be already in the early stages of the disease.The most important factor in delaying cognitive impairment in patients with cerebrovascular disease is early detection and early treatment.Patients with cerebrovascular diseases are often accompanied by high insulin levels,and compared with intracranial macroangiopathy,the level of insulin,c-peptide water(c-peptide)is more closely related to small cerebral vascular disease.This paper explores whether C-peptide can become an objective indicator of early warning and effective treatment of cognitive disorders associated with cerebrovascular disease,and at the same time provide new diagnostic ideas for the early diagnosis and treatment of CSVD-related cognitive disorders.Methods of study:The subjects were divided into four groups,including 30 healthy outpatients as control group,53 patients with normal cognitive function of cerebrovascular disease(CSVD group),and 57 patients with mild cognitive impairment(MCI group),in 46 patients with dementia(CSVaD group),MMSE and Mo CA scores were given to all patients,with CSVaD and MMSE and abnormal Mo CA scores,patients with abnormal MMSE and MOCA scores were evaluated with HIS and CDR.And FCP levels were measured in four groups,to evaluate the relationship between insulin,c-peptide and cognitive impairment in patients with cerebrovascular disease,and to evaluate the effect of Fasting Blood Glucose and diabetes on insulin and c-peptide levels.Results:1.Comparison of insulin levels in the four groups,CSVaD group> MCI group>CSVD group,there was no significant difference in insulin level between control group and CSVD group(p > 0.05).There was significant difference in insulin level between control group and MCI Group and CSVAD group(p < 0.05),there was significant difference in insulin level between CSVD group and MCI,CSVAD group(p < 0.05).2.There was significant difference in the level of c-peptide between the four groups,the CSVaD group > MCI Group > CSVD Group > Control Group,the level of C Peptide in control group was significantly different from that in CSVD,MCI and CSVaD groups(p < 0.05),and that in CSVD group was significantly different from that in CSVAD group(p < 0.05).3.There is a correlation between the degree of cognitive dysfunction of cerebrovascular disease and C peptide.4.Insulin level is related to the occurrence of cognitive impairment in cerebrovascular disease(P <0.05),and the correlation with the degree of cognitive impairment is not as obvious as C peptide.5.There was no correlation between insulin level and fasting blood glucose(P>0.05)and diabetes(P> 0.05).6.C-peptide levels were not related to fasting blood glucose(P> 0.05)and diabetes(P> 0.05).Conclusion:1.Compared with the insulin level,the CSVaD group > MCI Group > The normal cognitive function group,the difference between the normal cognitive function group and the control group was not significant.2.Compared with the level of c-peptide in patients with cerebrovascular disease,CSVaD group > MCI Group > CSVD Group > Control Group.3.The higher the degree of cognitive impairment,the higher the level of C-peptide and the lower the level of insulin in patients with cognitive impairment.4.Compared with traditional biomarkers(homocysteine,uric acid),c-peptide level can better reflect the degree of cognitive impairment in patients with Cerebral small vessel disease.