| Objective: This study intends to use Susceptibility Weighted Imaging(SWI)and Diffusion Tension Imaging(DTI)technologies,combined with neurocognitive function scales,such as MMSE(Mini-mental State Examination),Mo CA(Montreal Cognitive Assessment),ADL(Activity Daily Living)to assess the cognitive function of the participants,and study the correlation between the early imaging micro manifestations of CSVD(Cerebral Small Vessel Disease)and cognitive impairment.The combination of SWI and DTI is intended to provide more help for the study of CSVD and cognitive function.Methods: The study was divided into 3 groups,namely SWI positive group,SWI negative group and control group.From October 2019 to December 2020,85 patients in the Department of Neurology of Tai zhou City People’s Hospital were included as standard CSVD patients,and were further examined by the cranial magnetic resonance T2W1.Further improve the SWI examination and divide patients into SWI-positive group and SWI-negative group according to the presence or absence of CMBs.At the same time,60 people who met the entry criteria of the control group were recruited as the control group.Collected information of each subject(age,gender,years of education,previous history,of hypertension,smoking and drinking histroy,admission blood glucose and triglyceride,etc.).Completed head MRI examination(including TIWI、T2WI、SWI、FLAIR)and finished scales(MMSE,Mo CA,ADL).Due to the long DTI examination time,we randomly selected a certain proportion(about 33%)of the subjects from the SWI positive group,SWI negative group and control group to complete further DTI examination in onder to realize microstructure of brain tissue.Record the MMSE,MoCA,ADL scale scores,number of CMBs and DTI scalar FA(Fractional Anisotropy)value of each enrollee,and analyze whether the scale scores of the three groups are statistically significant,and analyze the correlation between the number of CMBs in the SWI positive group and the scale score,as well as the correlation between FA value and cognitive scale score of the three groups with significant differences,and finally draw a conclusion.Results:1.There are statistical differences in the MMSE,MoCA and ADL scores between the SWI positive group,SWI negative group and the control group(P<0.05),and the MoCA scores of the SWI positive group and SWI negative group are statistically different(P<0.05).The average scores of the cognitive scales of the control group,SWI-negative group and SWI-positive group showed a gradually decreasing trend.2.The number of CMBs in the SWI positive group was negatively correlated with MMSE,(r=-0.419,P=0.003)and Mo CA scores(r=-0.582,P=0.001).3.Compared with the control group,the FA values of the knees of the corpus callosum,the body of the corpus callosum,the pressure of the corpus callosum,the forelimbs of the bilateral internal capsule,and the bilateral upper longitudinal tract were all decreased in the SWI positive group.Compared with the control group,the FA values of the corpus callosum knee,corpus callosum body,and corpus callosum pressure in the SWI-negative group decreased,and the difference was statistically significant,which was statistically significant.Compared with the FA value of the control group,the SWI-positive group had more differences than the SWI-negative group,which was statistically significant.(P<0.05).4.There is a positive correlation between the FA value of Genu of corpus callosum of the SWI positive group and the Mo CA scale score(r=0.506,P=0.038).Conclusions:1.CSVD can lead to a decline in cognitive function,and the cognitive function decline in patients with CMBs of this type of cerebrovascular disease is more serious.2.In cerebrovascular disease,the presence of cerebral microhemorrhage is more likely to lead to microstructural changes in brain tissue.3.SWI combined with DTI indicated that the microstructural changes in the Genu of corpus callosum may play an important role in the cognitive decline caused by cerebral small vessel disease. |
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