Study On The Correlation Between Serum Vitamin D Levels And Metabolic Syndrome In Patients With Type 2 Diabetes

ObjectiveTo investigate the relationship between serum 25-hydroxyvitamin D3[25?OH?₂D₃]level and the risk of metabolic syndrome?MS?and its components in patients with type2 diabetes mellitus.MethodsClinical data of 796 T2DM patients admitted to the Department of Endocrinology,from January 2017 to December 2018 were selected.According to the diagnosis,541 cases of MS group and 255 cases of non-MS group were analyzed.The factors affecting serum vitamin D level were analyzed,and the correlation between serum vitamin D level and metabolic syndrome was discussed.ResultsThe level of 25?OH?D₃ in MS group was significantly lower than that in the control group?P<0.05?.The proportion of 25?OH?D₃ in MS group was significantly higher than that in non-MS group.The difference was statistically significant.Significance?P<0.001?3.Serum 25?OH?D₃ levels was significant negative correlation with smoking,body mass index?BMI?,systolic blood pressure,diastolic blood pressure,waist circumference,serum triglyceride?TG?levels,serum low density lipid and low density lipoprotein cholesterol?LDL-C?levels?P<0.05?.4.After adjusting for various confounders,multivariate logistic regression analysis showed that 25?OH?D₃ was the independent protective factors of MS in patients with type 2 diabetes.5.Patients were divided into 4 subgroups according to 25?OH?D₃ levels[0ng/mL?25?OH?D3<10ng/mL?n=24?,10ng/mL?25?OH?D3<20ng/mL?n=417?,20ng/mL?25?OH?D₃<30ng/mL?n=117?,25?OH?D₃?30ng/mL?n=18?].In the Q1 group as a control,logistic regression showed that the odds ratios?OR?for the risk of metabolic syndrome in the Q2,Q3,and Q4 groups were 0.471,0.389,and 0.211,respectively?both P<0.05?,and the trend test P-trend=0.03.ConclusionIn patients with type 2 diabetes,serum 25?OH?D3 levels are independently and inversely associated with MS risk.