Observation On The Effect Of Sufentanil Local Intra-articular Injection Combined With Patient-controlled Intravenous Analgesia On Postoperative Analgesia Of Unilateral Knee Arthroscopy

Objective:The safety,analgesic effect and adverse reaction rate of sufentanil injection combined with intravenous analgesia after unilateral knee arthroscopy were observed and compared with intravenous analgesia alone.Methods:A total of 60 patients who underwent unilateral knee arthroscopic surgery under general anesthesia in our hospital from June to December 2019 were enrolled in this study.All patients had an ASA grade of I^II,male and female unlimited,age 22-65 years old.All patients signed the postoperative informed consent.The patients were randomly divided into two groups:sufentanil PCIA group+NS intra-articular injection control group（group A）,sufentanil PCIA+sufentanil intra-articular injection（IA）experimental group（group B）,30 cases in each group.After operation,the patients were followed up at fixed points,and the pain visual analogue score（VAS score）of each group was recorded at rest and in motion（knee flexion）at 2 hours（T₁）,6 hours（T₂）,12 hours（T₃）,24hours（T₄）and 48 hours（T₅）after operation,the times of additional compression of analgesia pump and the use of analgesic remedy times were recorded,and the time of 2 hours（T₁）,6 hours（T₂）,12 hours（T₃）,24 hours（T₄）and 48 hours（T₅）after operation were recorded,the consciousness state,blood pressure,heart rate and SpO₂ of patients at each time point,and the occurrence of adverse reactions were counted.Statistical analysis with SPSS Satistics 25.Results:Compared with group A,the VAS scores of rest and movement（knee flexion）in group B were significantly reduced（p<0.05）,the number of PCIA compressions and analgesic remedy times in group B were lower than those in group A（p<0.05）;compared with group A,the incidence of nausea and vomiting,skin pruritus and other adverse reactions in group B were significantly reduced（p<0.05）;The patients in both groups were aware at all time points after operation,and there was no significant difference in monitoring blood pressure,heart rate and SpO2（p>0.05）.Conclusions:Sufentanil local intra-articular injection combined with patient-controlled intravenous analgesia can relieve postoperative pain significantly in patients undergoing knee arthroscopic surgery,and has obvious advantages.It is not only conducive to postoperative functional exercise,reduce the use of sufentanil intravenous analgesia,reduce the incidence of adverse reactions of intravenous sufentanil,and promote rapid recovery of patients.