Effect Of Dexmedetomidine Intra-articular Injection On Postoperative Pain In Knee Arthroscopic Surgery

Objective: To investigate the analgesia effect of dexmedetomidine which is given through intra-articular injection before arthroscopic knee surgery. To know the safety, effectiveness and patient satisfaction of dexmedetomidine in analgesia, besides, we also gave a survey to the amount of other comprehensive analgesic drugs, in order to provide references for the application of dexmedetomidine in the analgesia after arthroscopic operations.Methods: A retrospective survey which is conducted in Chengde Central Hospital of second Department of orthopedics from February 2014 to July 2014, totally we randomized to select the case material of 60 patients which had got elective arthroscopic knee surgery. ASA of the patients were classified as grade I or Ⅱ, whose aged is ranging from 45 to 65 years, all is for spinal anesthesia.The patients were randomly divided into two groups: D Group: dexmedetomidine had been given in the dose of 1 ug / kg diluted with saline to 20ml; L Group: ropivacaine had been given in the dose of 1.5mg / kg diluted with saline to 20 ml. Intra-articular injection of analgesic drugs was given to two groups of patient’s right after the removal of arthroscopic devices. We made a record of VAS score when the patients were at rest and during exercise and we also make the record of Ramsay sedation scores after operation. And the exact time to give analgesic drugs after operation for the first time and the dose of usage of Dezoxine for 24 hours.Results: The Differences of general conditions between the two groups were not statistically significant; in the first 24 hour after the operation,no significant difference had shown between the two groups in the resting VAS scores, while the average VAS during exercise in group L was lower than D group, and the difference was statistically significant(P<0.05). As for the exact time to give analgesic drugs after operation for the first time,the average time for group D was(192.0±40.5) min and group L was(201.0 ±54.0) min, and difference was not statistically significant; The dose of Dezocine in group D was(18.0±4.5) mg,which was higher than(11.0 ±4.0) mg in group L, and the difference between the two groups was statistically significant(P<0.05);No significant differences had shown in the signs between the two groups in the first 24 hours after the operation; meanwhile, No significant differences had shown in the Ramsay sedation scores between the two groups in the first 24 hours after the operation; No patients in both groups had claimed nonausea,vomiting, respiratory depression, cardiovascular events and other adverse events in the first 24 hours after the operation.Conclusions: Dexmedetomidine can be given through intra-articular way after knee arthroscopy operations, and is effective to provide a short period of time for the patients out of pain, and can maintain the stable cardiovascular system functions, and no adverse reactions has been claimed till now.