The Correlation Between The Severity Of Nonalcoholic Fatty Liver Evaluated With FibroScan And Carotid Atherosclerosis In Type 2 Diabetic Patients

Objective:To study the relationship between the severity of nonalcoholic fatty liver that evaluation with Fibro Scan elastography and carotid arteriosclerosis in type 2 diabetic patients.Methods:According to the inclusion and exclusion criteria,choosing type 2 diabetes patients hospitalized in Affiliated Hospital of Qinghai University from November 2018 to November 2019 were selected,The liver fat content of all patients was measured by Fibro Scan,The liver fat controlled attenuation parameter(CAP)was used to divide it into three groups: non fat group(30 cases),mild fatty liver group(30 cases),moderate fatty liver group(25 cases)and severe fatty liver group(30 cases).The carotid artery intima-media thickness(CIMT)was measured by carotid ultrasound in all patients,Collect Age,gender,blood pressure,height,weight,waist circumference,body mass index,fasting blood glucose,2-hour postprandial blood glucose,glycosylated hemoglobin,total bilirubin,direct bilirubin,indirect bilirubin,fasting insulin,2-hour postprandial insulin,fasting peptide,2hourpostprandial C-peptide,insulin secretion index,insulin resistance index,insulin antibody,urinary microalbumin,24 hours Urine protein,uric acid,thyrotropin,alanine aminotransferase,aspartate aminotransferase,?-glutamyltransferase,alkaline phosphatase,cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,Statistical analysis of all data.Results:1.There was significant difference in age of each group(P < 0.05).The age of non fatty liver group,mild group,moderate group and severe group increased gradually,the difference was statistically significant(P < 0.05);2.BMI,waist circumference and uric acid in each group were significantly different(P < 0.05);BMI,waist circumference and uric acid in fatty liver group were higher than those in non fatty liver group(P < 0.05),BMI of moderate and severe fatty liver group was higher than that of mild fatty liver group(P < 0.05),The uric acid in severe fatty liver group was higher than that in mild fatty liver group,The difference was statistically significant(P < 0.05);3.The weight ?TG?ALT?AST??-GGT?FBG?2h BG?FCP?2h CP?ISI?HOMA-IR?FINS?2h INS ?DBilof each group was statistically significant,and in the severe fatty liver group were higher than those in the non fatty liver group(P < 0.05);4.The carotid intima-media thickness of fatty liver group was greater than that of fatty liver group(P < 0.05);5.Age,uric acid,high pressure,low pressure,fatty liver severity,direct bilirubin were correlated with atherosclerosis(P < 0.05);Conclusions:1.Patients with type 2 diabetes mellitus and nonalcoholic fatty liver are more likely to develop carotid atherosclerosis.There is a tendency of arteriosclerosis in mild fatty liver.The degree of carotid atherosclerosis increased with the severity of NAFLD.Therefore,Fibro Scan should be used in patients with type 2 diabetes mellitus to dynamically monitor the liver fat content and actively treat fatty liver to prevent the development of atherosclerosis;2.The incidence of nonalcoholic fatty liver may be related to age,BMI,waist circumference,uric acid,body weight,ALT?AST??-GGT?FBG?2h BG?FCP?2h CP?TG?ISI?HOMA-IR?FINS?2h INS ?DBil.With the increase of age,waist circumference,body weight and BMI,we should measure the fat content of liver by Fibro Scan as soon as possible,and actively treat fatty liver.3.In addition to the severity of fatty liver,age,uric acid,blood pressure and direct bilirubin are also risk factors of atherosclerosis in type 2 diabetic patients.