Clinical Research Of P-hydroxyphenylalanine In Urine Of Patients With Early Gastric Cancer In Qinghai

Objective: Gastric cancer(GC)patients were tested for p-hydroxyphenylalanine in urine to analyze the positive detection rate of p-hydroxyphenylalanine in urine of patients with different stages of GC Changes in the situation,preliminary discussion of the application of p-hydroxyphenylalanine urine detection in early gastric cancer(EGC)diagnosis.Methods: From december 2018 to october 2019,90 inpatients who were diagnosed with GC and met the discharge criteria by histopathology at the affiliated hospital of qinghai university were collected as the test group,there were 30 cases each of EGC,Advanced Gastric Cancer(AGC),and Late Gastric Cancer(LGC);In addition,30 patients with chronic superficial gastritis(CSG),chronic atrophic gastritis(CAG),and gastric ulcer(GU)diagnosed by gastroscopy in our hospital during the same period were collected as controls.All subjects were tested for p-hydroxyphenylalanine urine(EGC and AGC patients were tested once before and on the 3rd day after surgery),and the data were analyzed statistically.Results: 1.The total positive detection rate of p-hydroxyphenylalanine in urine of GC group was 80.00%.The positive detection rates in the GU group,CAG group,and CSG group were 43.33%,40.00%,and 16.67%,respectively.The total positive detection rate of GC group was significantly higher than that of GU group,CAG group and CSG group(all P<0.05),the positive detection rate of GU group and CAG group was significantly higher than that of CSG group(all P<0.05).There was no significant difference in the positive detection rate between the GU group and the CAG group(P>0.05).2.In the GC group,the positive detection rates of p-hydroxyphenylalanine in urine of EGC,AGC,and LGC were 70.00%,76.67%,and 93.33%,which were gradually increasing.Among them,the positive detection rate of LGC group was significantly higher than that of EGC group(P<0.05),and there was no significant difference in positive detection rate between LGC group and AGC group,AGC group and EGC group(all P>0.05).3.The positive detection rate of p-hydroxyphenylalanine in urine of EGC group was significantly higher than that in the GU group,the CAG group and the CSG group(all P<0.05).4.There was no significant difference in the positive detection rate of p-hydroxyphenylalanine in urine before and after ESD in patients with EGC and before and after surgery in AGC patients(70.00% vs 63.33%,76.67% vs 80.00%,all P>0.05).5.p-hydroxyphenylalanine urine test has a sensitivity of 80.00% for GC diagnosis and a specificity of 66.67%;Kappa value of p-hydroxyphenylalanine urine test compared with pathological diagnosis is 0.47,indicating that the urine test of p-hydroxyphenylalanine was moderately consistent with the pathological diagnosis in the diagnosis of GC.At the same time,the paired chi-square test was used for the diagnosis of GC by the two detection methods,and the results were not statistically different(P>0.05).Conclusions: 1.P-hydroxyphenylalanine urine test can be used as an important auxiliary method for the diagnosis of EGC.2.The positive rate of p-hydroxyphenylalanine urine test in GC patients gradually increased with the deterioration and progress of the disease.3.The p-hydroxyphenylalanine urine test is suitable for large-scale screening of high-risk GC populations.For patients with precancerous diseases such as GU and CAG with positive test results,through dynamic monitoring and timely intervention,EGC can be detected and diagnosed early,and the detection rate of GC can be greatly improved.4.Within 3 days after operation,the positive detection rate of p-hydroxyphenylalanine in urine of EGC and AGC was not significantly different from that before operation.