Clinical Effect Of Enteral Nutrition Through Jejunal Nutrition Tube In The Treatment Of Severe Acute Pancreatitis

Objective To compare the clinical effect of enteral nutrition via jejunal nutrition tube and complete parenteral nutrition in the treatment of severe acute pancreatitis(SAP),and investigate the advantages and value of enteral nutrition in the treatment of SAP.Methods Patients who were admitted to General Hospital of Ningxia Medical University and diagnosed with SAP on January 1,2015 and September 1,2019 were collected.100 SAP patients who met the inclusion criteria were screened out and divided into enteral nutrition group(EN group 48 cases)and parenteral nutrition group(PN group 52 cases)according to different nutritional treatments.After admission,both groups were initially treated with liquid resuscitation,after the hemodynamics of the patients were alleviated,the EN group was generally treated with enteral nutrition therapy with a jejunotrophic tube within72 hours,and parenteral nutrition support was provided for the part with insufficient energy,while the PN group was fully treated with parenteral nutrition support.The relevant laboratory indicators,system inflammatory response syndrome(SIRS)scores,modified computed tomography severity index(MCTSI)scores and bedside index of severity in acute pancreatitis(BISAP)scores of the two groups were compared on the seventh day after treatment.The differences of blood amylase recovery time,secondary infection rate,surgical intervention rate,mortality rate,hospitalization duration and hospitalization cost were analyzed.Results There was no significant difference in the general characteristic data,diseaseseverity and clinical observation indexes of the two groups at admission(P>0.05).The laboratory indicators and clinical prognosis of both groups improved after 7 days of management and nursing support treatment,compared with PN group,the CRP level,lymphocyte,blood glucose,blood calcium,relative SIRS score of EN group improved more significant,difference was statistically significant(P<0.05).However,there was no significant difference in the improvement of white blood cell count,albumin,MCTSI and BISAP scores between EN group and PN group after treatment(P>0.05).After treatment,secondary infection rate,length of hospital stay,hospital expenses of EN group was lower than those of PN group obviously,the difference was statistically significant(P<0.05),and there was no significant difference in blood amylase recovery time,surgical intervention rate and mortality between EN group and PN group(P>0.05).Conclusion Compared with parenteral nutrition,early enteral nutrition support treatment through jejunal nutrition tube can significantly improve the clinical condition of SAP patients,effectively protect the function of intestinal barrier and exert the immune effect,reduce the displacement of intestinal flora,cut down the inflammatory index of the body,improve the nutritional status,and prevent the occurrence of secondary infection,in addition,it can shorten the hospitalization time of patients and save the cost of hospitalization.