Study On The Relationship Between Renal Damage And Blood Gas Analysis?Pulmonary Function In Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective:The renal function indexes in patients with AECOPD and healthy people were collected and make analysis,explore whether there is renal damage in patients with AECOPD,and to analysis the relationship between renal function indexes and blood gas analysis?pulmonary function.Methods:1.A total of 111 patients with acute exacerbation of chronic obstructive pulmonary disease?AECOPD group?were collected,and 55 healthy subjects were selected as the control group.Some indicators were recorded,such as general clinical data{?age,sex,height,weight,body mass index?BMI??,renal function indicators{serum creatinine?Scr?,serum urea nitrogen?BUN?,glomerular filtration rate?GRF?,serum cystatin C?Cys-C?,serum?2-microglobulin??2-MG?},arterial blood gas index{partial pressure of oxygen?PO₂?,partial pressure of carbon dioxide?PCO₂?},Pulmonary function index{forced expiratory volume in one second/forced vital capacity?FEV1/FVC?,percentage of forced expiratory volume in one second to predicted value?FEV1%pre?},etc.2.The differences of general data,renal function index,arterial blood gas index and pulmonary function index between the two groups were statistically analyzed.3.The renal function of patients with different groups of AECOPD was analyzed and compared with that of the control group.4.The correlation between renal function index,blood gas index and pulmonary function index in patients with AECOPD was statistically analyzed.Results:1.There were no significant difference in gender?male/female?,age,height weight,BMI and BUN between AECOPD group and control group?P>0.05?,There were significant differences in PO₂,PCO₂,FEV1%pre,FEV1/FVC,Scr,GFR,Cys-C and?2-MG between the two groups?P<0.05?.2.Comparison among the control group,mild to moderate group and severe extremely severe group:there was no significant difference in BUN among the three groups.There were significant differences in Scr,GFR,Cys-C and?2-MG among the three groups.3.In AECOPD group,Scr,GFR,Cys-C and?2-MG were used as dependent variables to analyze the correlation with blood gas and pulmonary function indexes.The study found that Scr is negatively correlated with PO₂,FEV1%pre and FEV1/FVC?r=-0.267,P=0.005;r=-0.297,P=0.002;r=-0.309,P=0.001?,Scr is positively correlated with PCO₂?r=0.236,P=0.012?;GFR is positively correlated with PO₂,FEV1%pre,and FEV1/FVC?r=0.375,P=0.000;r=0.224,P=0.018;r=0.261,P=0.006?,and it shows a positive correlation with PCO₂ negative correlation?r=-0.229,P=0.016?;Cys-C was negatively correlated with PO₂?r=-0.404,P=0.000?,Cys-C was positively correlated with PCO₂?r=0.249,P=0.008?;?2-MG is negatively correlated with PO₂,FEV1%pre,FEV1/FVC?r=-0.423,P=0.000;r=-0.253,P=0.007;r=-0.289,P=0.002?,?2-MG is positive with PCO₂ correlation?r=0.348,P=0.000?.4.In AECOPD group,taking Scr,GFR,Cys-C and?2-MG as dependent variables and blood gas and pulmonary function indexes as independent variables,multiple linear regression analysis was carried out.It was found that there was a correlation between Scr and P0₂??=-0.270,P=0.030?when Scr was used as dependent variable.;When GFR was taken as the dependent variable,it was found that GFR was related to P0₂??=0.329,P=0.009?;When Cys-C was taken as the dependent variable,it was found that Cys-C was related to P0₂??=-0.352,P=0.005?;When?2-MG was used as the dependent variable,it was found that?2-MG was related to P0₂??=-0.262,P=0.029?.Conclusion:1.There is renal function damage in patients with AECOPD,and the degree of renal function damage may be aggravated with the aggravation of airflow limitation in AECOPD patients.2.Partial pressure of oxygen may be related to renal function in patients with AECOPD,and hypoxia may be a risk factor for renal function damage in patients with AECOPD.