| Background High concentration of serum 25(OH)D cells can maintain the normal metabolism of 25(OH)D receptors in human skeletal exocytes,which is closely related to the development of blood circulation system,respiratory system,connective tissue,autoimmunity and tumors.Some studies had shown that supplementation of 25(OH)D3at 4000 U per day can significantly reduce the incidence of infection symptoms,number of pathogenic bacteria in nasal swabs and the consumption of antibiotics.It can also reduce the incidence of recurrent respiratory tract infections in children due to imperfect immune function.The titer of hepatitis B surface antibody(anti-HBs)indicates the levels of response to hepatitis b vaccine in children,which mainly reflects the strength of cellular immune function in children.In this study,we aimed to validate the associations between the concentration of 25(OH)D and immune function as well as recurrent respiratory tract infections in children.Objective To evaluate the distribution of serum 25-hydroxyvitamin D(25(OH)D)concentrations in children with different levels of immunoglobulin G and M(IgG and IgM),and to further analyze the associations between 25(OH)D and hepatitis B antibody titers(anti-HBs)as well as recurrent respiratory infections.Methods A total of146 children with recurrent respiratory infections at First Affiliated Hospital of Anhui Medical University from August 2016 to October 2018 were included in the present study.According to the age,patients were divided into different groups: 0?2 years old,2?6 years old,6?12 years old and 12?16 years old.Serum 25(OH)D was assessed between different groups.Additionally,patients were grouped by the levels of serum IgG and IgM: 79 cases in IgG reduction group,38 cases in normal IgG group and 30 cases in elevated IgG group,92 cases in IgM reduction group,29 cases in normal IgM group and 25 cases in elevated IgM group.Serum 25(OH)D was evaluated in different groups to determine the relationship between the levels of Serum 25(OH)D and IgG,IgM.Poisson regression models were used to evaluate the associations between serum25(OH)D concentration and the number of repeated respiratory infections in children,which were showed by frequency ration(FR)and 95% confidence intervals(CI).Results Compared to 2?6 group,6?12 group and 12?16 group,0?2 years old group had higher(q=5.202,6.030,8.432,P <0.001).Serum 25(OH)D levels in 2?6 years old and6?12 years old group were higher than 12-16 years old(q=5.317,5.559,P<0.05).The difference of serum 25(OH)D level between IgG groups was statistically significant(q=4.287,P<0.05).Serum 25(OH)D level in IgG normal group was higher than that in IgG decreased group and IgG increased group,and the difference was statistically significant(q=5.213,4.990,b P<0.01).The serum 25(OH)D level of IgG increased group was higher than that of IgG decreased group,and the difference was statistically significant(q=5.008,a P<0.01).There was no significant difference in serum 25(OH)D level between IgM normal group and IgM elevated group(q=1.278,b P>0.05).Serum25(OH)D level in the normal IgM group and the IgM elevated group was higher than that in the IgM decreased group,with statistically significant differences(q=4.945,4.577,a P<0.05).Linear regression analysis indicated that serum 25(OH)D level was positively correlated with anti-HBs titer.After adjusting the age,gender,serum IgG and IgM in the Poisson regression models,increased level of serum 25(OH)D was negatively associated with the number of repeated respiratory infections in children(FR=0.94,95%CI=0.89-1.03,P =0.053).Conclusion Serum 25-hydroxyvitamin D(25(OH)D)concentration was positively associated with serum anti-HBs titer,but negatively associated with serum IgG concentration and the number of recurrent respiratory tract infections in children. |
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