Impact Of Mean Platelet Volume On Prognosis In Patients With ST-Elevation Myocardial Infarction

Objective: To evaluate the impact of mean platelet volume(MPV)on prognosis in patients with ST-segment elevation myocardial infarction(STEMI).Methods: A total of 1012 consecutive STEMI patients received percutaneous coronary intervention(PCI)in our hospital from 2010-01-01 to 2014-10-31 were enrolled.Major adverse cardiovascular events(MACE)were recorded in 2015-10.Based on ROC curve measured optimal critical point of MPV in all-cause death,the patients were divided into Low MPV group and High MPV group.The incidence of MACE was compared between 2 groups,the impact of MPV on prognosis of PCI treated STEMI patients was studied by uni-and multivariate COX regression analysis.Results: By ROC curve,the optimal critical point of MPV in all-cause death was MPV?9.466.MPV?9.466 in Low MPV group,n=549 and MPV>9.466 in High MPV group,n=463.The patients were followed-up for 34(12-69)months.Compared with Low MPV group,the patients in High MPV group had the higher incidences of all-cause death and cardiac death,P<0.001 and P=0.001.With adjusted multivariates,COX regression analysis showed that MPV was an independent risk factor of all-cause death(HR=1.463,P<0.001)and cardiac death(HR=1.458,P<0.001)in relevant patients.Conclusions: Increased MPV at admission had the predictive value for long-term prognosis in PCI treated STEMI patients.