Calcitonin In Fine Needle Aspirate Washoutfluid From Non-medullary Thyroid Carcinoma Nodules And Influencing Factors Analysis

Objective To investigate the calcitonin in fine needle aspirate washout fluid(FNA-CT)in non-medullary thyroid carcinoma(non-MTC)nodules and its influencing factors.Methods The clinical data of patients admitted to the Department of Endocrinology,the First Affiliated Hospital of Chongqing University due to thyroid nodules from January 2017 to January 2018 were retrospectively analyzed,including sex,age,ultrasound(location,size,echo,TI-RADS),fine-needle aspiration cytology(FNAC),serum calcitonin(sCT),FNA-CT.335 non-MTC nodules from 301 patients were included.The levels of FNA-CT and its influencing factors were analyzed.Results FNA-CT was detected in 37.6%(126/335)of non-MTC nodules,with values from 0.51 to 2000pg/ml(median 16.51pg/ml).The level of FNA-CT in males was higher than that in females(P=0.017).The FNA-CT level of the middle pole nodules was significantly higher than that of the upper and the lower pole(P=0.001).Comparison of results fordifferent age and FNAC,there was no significant difference in level of FNA-CT among non-MTC nodules(P>0.05).Comparison of results for different ultrasound feature(such as echo property,size,TI-RADS grading and FNA Bethesda classification),there was also no significant difference in FNA-CT level.In addition,no significant correlation(r=0.123,p=0.171)was found between FNA-CT and sCT.Conclusions Calcitonin can be detected in 37.6% of non-MTC nodules aspiration eluents.The highest level of FNA-CT in non-MTC nodules is 2000pg/ml.Sex and node location are the influencing factors for FNA-CT in non-MTC nodules.sCT,FNAC,US features such as diameter sizes,the echogenicity,TI-RADS grading have no influence on FNA-CT.