| ObjectiveBy observing Liuzijue’s TCM syndrome scores,immune inflammatory factor express ion and clinical symptoms changes in patients with COPD stable stage,the effects of Li uzijue on COPD patients’ Qi deficiency syndrome and immune function were analyzed,and from immune inflammation Factor expression levels explore the mechanism of Liuzi jue’s clinical rehabilitation in patients with stable COPD.MethodsThe subjects of this study were 74 patients with stable COPD who were treated in the outpatient department of the Department of Pulmonology,Jinjiang Hospital of Tradi tional Chinese Medicine,from March 2019 to June 2019.The random number table desi gned by SPSS22.0 statistical software was divided into experimental groups(n=37)and control group(n=37).The control group was given conventional drug treatment and nurs ing,and the experimental group was trained on the basis of Liuzijue.The training stand ard was based on "Fitness Qigong · Liuzijue" edited by the Health Qigong Management Center of the State Sports General Administration.The training program is 30mins/time,1 time/day,5 days/week,a total of 6 months,and the training time is calculated by th e cumulative amount.The effects of the two groups of patients before and after 6 mont hs of intervention were evaluated respectively.Outcome indicators included:(1)TCM syn drome scores,which were evaluated using the qi-deficiency syndrome grading scale;(2)p eripheral blood and induced sputum inflammation factors IL-8,IL-10,TNF-α expression,measured by ELISA method;(3)peripheral blood and induced sputum immune factor No tch1 mRNA expression,measured by qPCR method;(4)difficulty breathing,using mMRC questionnaire assessment;(5)exercise endurance,using 6MWT assessment;(6)quality of lif e,Using CAT scale evaluation.According to the combination of PP analysis and ITT ana lysis,the impact of Liuzijue on it is evaluated.ResultsA total of 74 eligible subjects were included in the study.After the intervention,a total of 57 cases completed the study.Among them,2 cases were eliminated in the experimental group and 8 cases were lost,and 27 cases were completed.In the contr ol group,1 case was eliminated and 6 cases were dropped,and 30 cases were compl eted.Therefore,PP analysis was performed on 27 cases in the experimental group and 30 cases in the control group;ITT analysis was performed on 37 cases in the experi mental group and 37 cases in the control group.1 Comparison of baseline dataGeneral information of the two groups of patients(gender,age,body mass index,smoking index,course of disease,conventional drug treatment plan,home oxygen the rapy)and outcome indicators(TCM syndrome score,blood and sputum inflammation f actors IL-8,IL-10,TNF-α expression,immune factor Notch1 mRNA expression,degree of dyspnea,exercise tolerance,quality of life)before the intervention,the difference was not statistically significant(P>0.05),suggesting that the baseline data of the two groups are comparable.2 Evaluation of intervention effect2.1 TCM syndrome pointsPP analysis results showed that the total scores of Qi deficiency syndrome and the scores of primary and secondary symptoms in the two groups were significantly lower t han those before the intervention.The P values of the experimental group were 0.000,0.000,0.001,and the P values of the control group were 0.000,0.000,0.001,the results of ITT analysis are basically consistent with them;there is no statistically significant dif ference in the total scores of Qi deficiency syndrome and the scores of primary and sec ondary syndromes and the total clinical effective rate after intervention in the experiment al group compared with the control group(P>0.05),However,it is suggested that the to tal score of Qi deficiency syndrome(3(2-4))and the score of main symptoms(3(2-3))i n the experimental group are higher than the total score of Qi deficiency syndrome(4(3-5))and the score of main symptoms(3(2-4))in the control group showed a downward trend,the total clinical effective rate(66.7%)was higher than that of the control group(53.3%),and the results of ITT analysis were basically consistent with it.2.2 Expression of inflammatory factorsPP analysis results showed that the levels of blood and sputum inflammatory factor s IL-8,IL-10,and TNF-α in the two groups were lower than those before the interventi on,and the blood IL-10 and blood TNF-α in the experimental group were compared wit h the intervention.Significantly decreased before,with P values of 0.000 and 0.012,res pectively,and blood IL-8,sputum IL-8,blood IL-10,sputum IL-10,and blood TNF-α in the control group decreased significantly compared with before intervention,with P val ues of 0.003,0.028,0.000,0.035,0.001,the results of ITT analysis are basically consist ent with them;the blood IL-8 and IL-10 expression levels of patients in the experiment al group after intervention are significantly higher than the control group,P values are0.016,0.030,and others There was no statistically significant difference in the expressio n levels of inflammatory factors between groups(P>0.05).The results of ITT analysis s howed that the blood and sputum inflammatory factors IL-8,IL-10,and TNF-α in the e xperimental group were not statistically different from the control group after interventio n.Academic significance(P>0.05).2.3 Expression of immune factorsPP analysis results showed that the blood and sputum immune factor Notch1 mRNA expression levels of the two groups were lower than before the intervention.Among th em,the blood Notch1 mRNA of the experimental group was significantly lower than bef ore the intervention,P value was 0.003,and the sputum Notch1 mRNA expression level was compared before and after the group The difference was not statistically significant(P>0.05).The blood Notch1 mRNA in the control group was significantly lower than bef ore the intervention.The P value was 0.000.The expression level of sputum Notch1 mR NA in the group was not statistically different before and after the group(P>0.05).Ther e was no significant difference between the two groups in the blood and sputum immun e factor Notch1 mRNA expression levels of the experimental group compared with the co ntrol group(P>0.05),and the results of ITT analysis were basically consistent.2.4 Degree of difficulty in breathingPP analysis results showed that the mMRC grades of the two groups were significa ntly lower than those before the intervention.The P value of the experimental group wa s 0.010,and the P value of the control group was 0.041.The ITT analysis showed that the mMRC grade of the experimental group was significantly more than before the intervention.Decreased,P value was 0.028,there was no statistically significant difference between the control group and the mMRC grade before and after the group(P>0.05);b etween groups,there was no statistically significant difference between the experimental group and the control group after intervention(P>0.05),But it suggests that the impro vement degree of mMRC classification in the experimental group(level 0 accounted for11(40.7%),level 1 accounted for 12(44.4%),level 2 accounted for 4(14.8%))compa red with the control group(level 0 accounted for 10(33.3%),level 1 accounted for 12(40.0%),level 2 accounted for 7(23.3%),and level 3 accounted for 1(3.3%).The resu lts of ITT analysis were basically consistent.2.5 Sports endurancePP analysis results showed that the 6MWD of the two groups of patients in the gr oup was significantly increased compared with that before the intervention.Among them,the P value of the experimental group was 0.000,and the P value of the control grou p was 0.000.The ITT analysis results were basically consistent with it;After 6MWD an d 6MWD increased value was significantly higher than the control group,P value was0.030,0.000,ITT analysis results showed that the 6MWD increase value of the experim ental group after intervention was significantly higher than the control group,P value w as 0.001,6MWD compared with the control group no statistical difference Academic sig nificance(P>0.05).2.6 Quality of lifePP analysis results showed that the total CAT scores and various scores of the two groups of patients in the group were significantly lower than before the intervention(P<0.05),of which the P values of the experimental group were 0.000,0.000,0.000,0.000,0.000,0.004,0.004,0.000,0.000,the P value of the control group was 0.000,and t he results of ITT analysis were basically consistent with it;the total CAT score and sle ep and energy scores of the experimental group after intervention were significantly low er than those of the control group,P values were 0.045,0.003,0.010,and At the same time,the scores of patients in the experimental group on housework activities(1(1-2))and confidence in going out(2(1-2))were lower than those in the control group on hou sework activities(2(1-2))and confidence in going out(2(1-3)).The results of ITT analy sis showed that the total CAT score and various scores of the patients in the experiment al group after intervention were not statistically different from those in the control group(P>0.05),but the patients in the experimental group were coughing(2(1-2)),gasp(3(2-3)),sleep(2(2-3)),energy(2(2-3))scores were higher than the control group cough(2(2-3)),gasp(3(2-4)),sleep(3(2-3)),energy(3(2-3))showed a downward trend.Conclusion1.Liuzijue training can regulate the expression level of immune inflammatory factors in patients with COPD to a certain extent,help patients maintain a pro-infla mmatory and anti-inflammatory balance in the body,improve the inflammatory resp onse and enhance the body’s immunity.2.Liuzijue training can help COPD patients improve their syndrome of Qi def iciency syndrome,degree of dyspnea,exercise endurance and quality of life. |
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