Study On The Relationship Between Nutritional Status And Inflammatory Response In AECOPD

Objective: To study the correlation between inflammatory reaction and malnutrition in patients with AECOPD and to explore the causes of malnutrition in COPD.Methods: 88 patients with AECOPD were divided into malnutrition group and normal nutrition group.The height,weight,defatted body mass,white blood cell,C-reactive protein,hemoglobin,human serum albumin,hospital stay and hospitalization expenses were collected,and the correlation between nutritional status and inflammation index,hospitalization time and hospitalization cost was analyzed.Results: 1.A total of 88 patients with AECOPD were included,including 35 patients with normal nutrition and 53 patients with malnutrition.The incidence of malnutrition was 60.2%.There was no significant difference in age and sex ratio between the two groups.2.The BMI,skeletal muscle index,albumin and hemoglobin in the malnutrition group were lower than those in the normal nutrition group,while the CRP in the malnutrition group was higher than that in the normal nutrition group,and the difference was statistically significant.3.The length of stay and cost of hospitalization in the malnutrition group were higher than those in the normal nutrition group,and the difference was statistically significant.Conclusion: 1.CRP is generally increased in patients with AECOPD,especially in patients with malnutrition,indicating that CRP is not only a marker of acute inflammation,but also related to the nutritional status of patients with AECOPD.High serum CRP may be one of the risk factors for the decrease of FFMI.2.Patients with malnutrition in AECOPD are more likely to have decreased body mass and skeletal muscle mass,hypoproteinemia and anemia,3.Malnutrition will cause COPD patients to prolong the length of stay and increase the cost of hospitallization.