The Clinical Efficacy Observation Of Huayu Changshen Decoction In The Treatment Of Generalized Anxiety Disorder For Liver-qi Stagnation Type

Objective:This research aims research the clinical efficacy and safety of Huayu Changshen Decoction combined with paroxetine hydrochloride by observing the changes of clinical symptoms,Hamilton anxiety score,traditional Chinese medicine symptom score and other indexes of patients before and after the treatment of generalized anxiety disorder of liver-qi stagnation with Huayu Changshen Decoction.Methods:This research adopts the randomized controlled research method.The research objects were from the clinic and ward of the Department of Encephalopathy of Xiamen Hospital of Traditional Chinese Medicine affiliated to Fujian University of Traditional Chinese Medicine and the Department of Psychiatry of Xiamen Xianyue Hospital.A total of78 patients with generalized anxiety disorder were included,which were randomly divided into the observation group(39 cases)and the control group(39 cases).The control group was given paroxetine hydrochloride orally.The observation group was given a dose of traditional Chinese medicine decoction " Huayu Changshen Decoction" with the same dose of paroxetine hydrochloride orally,with continuous observation for 12 weeks.By observing the changes of clinical symptoms,HAMA scores and raditional Chinese medicine symptom score before and after treatment,and taking liver and kidney function and electrocardiogram as safety indicators,the effectiveness and safety of "Huayu Changshen Decoction" were evaluated by statistical analysis.Results:1.A total of 78 patients were included in this study,72 of which completed clinical observation,3 drop-out in the observation group and 3 drop-out in the control group,with a total drop-out rate of 7.69%.2.There was no statistical significance in gender,age,course of disease,Score level of HAMA,HAMA score,single TCM symptom distribution and traditional Chinese medicine symptom score between the two groups(P>0.05);(2)Traditional Chinese medicine symptom score: compared with the two groups,anxiety and related clinical symptoms were obviously improved(P<0.01);compared with the two groups in the same period,there was significant difference between the two groups after 4 weeks of treatment(P<0.05),but there was significant difference and significant reduction after 8 and 12 weeks of treatment(P<0.01).(3)HAMA score:compared with the two groups,both groups can significantly reduce the HAMA score(P<0.01);Comparing the same period,the scores of the two groups were different after 4w and 8w treatment(P<0.05),and the decline degree of the score in the observation group was more significant after 12 weeks of treatment(P<0.01).3.Overall clinical efficacy: the total effective rate of the observation group was 88.89%,and that of the control group was 77.78%.The clinical efficacy of the two groups was highly statistically significant(P<0.01).4.Safety analysis: No adverse events in the observation group;2 adverse events in the control group:including nausea(1 case),dry mouth(1 case)were observed in control group during the first week of treatment.After the assessment of the correlation between adverse events and experimental drugs,it was considered that the adverse reactions might be related to drugs,The degree of adverse reactions was mild,and the symptoms disappeared without special treatment within two weeks,the patient continued to participate in clinical observationuntil the end of the study.the comparison of adverse events between the two groups was not statistically significant(P>0.05).No abnormal changes were found in the laboratory indexes such as liver and kidney function and electrocardiogram,and there was no significant difference between the two groups before and after treatment(P>0.05).Conclusion: Huayu Changshen Decoction combined with paroxetine hydrochloride is effective in treating the generalized anxiety disorder of liver-qi stagnation.It has more advantages than paroxetine hydrochloride alone in improving traditional Chinese medicine symptom score and HAMA score,and can better improve the life quality of patients.It has good safety without obvious adverse reactions.